Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CAMK2D | Q13557 | 3/20 | 0.61 |
| ▸ | JAK2 | O60674 | 9/20 | 0.57 |
| ▸ | MAPK8 | P45983 | 4/20 | 0.56 |
| ▸ | MAPK10 | P53779 | 4/20 | 0.56 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.52 |
| ▸ | ABL1 | P00519 | 1/20 | 0.50 |
| ▸ | BCR | P11274 | 1/20 | 0.50 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.49 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.49 |
| ▸ | STK17A | Q9UEE5 | 2/20 | 0.49 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.49 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.49 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.49 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.49 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.49 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.49 |
| ▸ | MYLK4 | Q86YV6 | 1/20 | 0.49 |
| ▸ | JAK1 | P23458 | 1/20 | 0.48 |
| ▸ | JAK3 | P52333 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3758337 | 0.92 | MAPK8 (0.67) | CAMK2DJAK2MAPK8MAPK10MAPK9 | |
| SCHEMBL4375206 | 0.82 | JAK2 (0.68) | CAMK2DJAK2MAPK8MAPK10MAPK9 | |
| SCHEMBL16404665 | 0.80 | CAMK2D (0.59) | CAMK2DJAK2MAPK8MAPK10MAPK9 | |
| SCHEMBL3750806 | 0.76 | MAPK8 (0.82) | CAMK2DJAK2MAPK8MAPK10MAPK9 | |
| SCHEMBL3751647 | 0.76 | MAPK8 (0.67) | CAMK2DJAK2MAPK8MAPK10MAPK9 | |
| SCHEMBL16404663 | 0.75 | CAMK2D (0.59) | CAMK2DJAK2MAPK8MAPK10MAPK9 | |
| SCHEMBL3751044 | 0.75 | MAPK8 (0.68) | CAMK2DJAK2MAPK8MAPK10MAPK9 | |
| SCHEMBL3754113 | 0.75 | MAPK8 (0.66) | CAMK2DJAK2MAPK8MAPK10MAPK9 | |
| SCHEMBL3753705 | 0.73 | MAPK8 (0.64) | CAMK2DJAK2MAPK8MAPK10MAPK9 | |
| SCHEMBL3753651 | 0.73 | MAPK8 (0.75) | CAMK2DJAK2MAPK8MAPK10MAPK9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2200436-B1 | SUBSTITUTED PYRIMIDINYL-AMINES AS PROTEIN KINASE INHIBITORS | SCRIPPS RESEARCH INST (US) | 2015-01-21 | — | — | EP | disclosed |