Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK8 | P45983 | 3/20 | 0.45 |
| ▸ | MAPK10 | P53779 | 3/20 | 0.45 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.45 |
| ▸ | JAK2 | O60674 | 4/20 | 0.36 |
| ▸ | JAK3 | P52333 | 3/20 | 0.36 |
| ▸ | EGFR | P00533 | 3/20 | 0.36 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.34 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.33 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.33 |
| ▸ | CDK2 | P24941 | 2/20 | 0.33 |
| ▸ | CCNA1 | P78396 | 2/20 | 0.33 |
| ▸ | FLT3 | P36888 | 1/20 | 0.32 |
| ▸ | STK17A | Q9UEE5 | 2/20 | 0.32 |
| ▸ | SYK | P43405 | 1/20 | 0.32 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.31 |
| ▸ | FAAH | O00519 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3756330 | 0.85 | MAPK10 (0.63) | MAPK8MAPK10MAPK9JAK2JAK3 | |
| SCHEMBL3760321 | 0.76 | MAPK10 (0.62) | MAPK8MAPK10MAPK9JAK2SYK | |
| SCHEMBL3760337 | 0.74 | MAPK10 (0.74) | MAPK8MAPK10MAPK9JAK2EGFR | |
| SCHEMBL3956266 | 0.74 | JAK2 (0.47) | MAPK8MAPK10MAPK9JAK2JAK3 | |
| SCHEMBL3765330 | 0.73 | MAPK10 (0.80) | MAPK8MAPK10MAPK9JAK2 | |
| SCHEMBL3752899 | 0.72 | MAPK8 (0.80) | MAPK8MAPK10MAPK9JAK2JAK3 | |
| SCHEMBL3751033 | 0.70 | MAPK10 (0.88) | MAPK8MAPK10MAPK9JAK2JAK3 | |
| SCHEMBL3753756 | 0.66 | MAPK10 (0.56) | MAPK8MAPK10MAPK9JAK2JAK3 | |
| SCHEMBL8052958 | 0.66 | JAK2 (0.39) | MAPK8MAPK10MAPK9JAK2JAK3 | |
| SCHEMBL3753023 | 0.65 | MAPK8 (0.53) | MAPK8MAPK10MAPK9JAK2JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2200436-B1 | SUBSTITUTED PYRIMIDINYL-AMINES AS PROTEIN KINASE INHIBITORS | SCRIPPS RESEARCH INST (US) | 2015-01-21 | — | — | EP | disclosed |