Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 3/20 | 0.39 |
| ▸ | JAK3 | P52333 | 3/20 | 0.39 |
| ▸ | CDK2 | P24941 | 5/20 | 0.38 |
| ▸ | CCNA2 | P20248 | 4/20 | 0.38 |
| ▸ | CCNA1 | P78396 | 4/20 | 0.38 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.37 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.37 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.37 |
| ▸ | SYK | P43405 | 1/20 | 0.35 |
| ▸ | IKBKB | O14920 | 1/20 | 0.35 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.35 |
| ▸ | EGFR | P00533 | 1/20 | 0.35 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.35 |
| ▸ | CDK4 | P11802 | 2/20 | 0.35 |
| ▸ | PIM1 | P11309 | 1/20 | 0.35 |
| ▸ | CCND3 | P30281 | 1/20 | 0.35 |
| ▸ | MTOR | P42345 | 1/20 | 0.35 |
| ▸ | GSK3B | P49841 | 1/20 | 0.35 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8058010 | 0.86 | MAPK8 (0.52) | JAK2JAK3MAPK8MAPK10MAPK9 | |
| SCHEMBL3956266 | 0.74 | JAK2 (0.47) | JAK2JAK3CDK2CCNA2CCNA1 | |
| SCHEMBL3756330 | 0.74 | MAPK10 (0.63) | JAK2JAK3MAPK8MAPK10KCNH2 | |
| SCHEMBL13081436 | 0.70 | MAPK8 (0.52) | JAK2JAK3MAPK8MAPK10MAPK9 | |
| SCHEMBL8042573 | 0.70 | JAK2 (0.42) | JAK2JAK3CDK2CCNA2CCNA1 | |
| SCHEMBL3760337 | 0.68 | MAPK10 (0.74) | JAK2CDK2CCNA2CCNA1MAPK8 | |
| SCHEMBL16404685 | 0.66 | MAPK8 (0.45) | JAK2JAK3CDK2CCNA2CCNA1 | |
| SCHEMBL13081061 | 0.66 | MAPK8 (0.56) | JAK2JAK3MAPK8MAPK10MAPK9 | |
| SCHEMBL3760321 | 0.66 | MAPK10 (0.62) | JAK2MAPK8MAPK10KCNH2SYK | |
| SCHEMBL13081434 | 0.65 | MAPK8 (0.58) | JAK2JAK3MAPK8MAPK10MAPK9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009032861-A1 | SUBSTITUTED PYRIMIDINYL-AMINES AS PROTEIN KINASE INHIBITORS | THE SCRIPPS RESEARCH INSTITUTE (US) | 2009-03-12 | — | — | WO | disclosed |