Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACAT2 | Q9BWD1 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | KCNQ2 | O43526 | 2/20 | 0.31 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.31 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.30 |
| ▸ | THRB | P10828 | 1/20 | 0.30 |
| ▸ | HTT | P42858 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16410761 | 0.75 | ACAT2 (0.40) | ACAT2 | |
| SCHEMBL16410646 | 0.72 | ACAT2 (0.32) | ACAT2 | |
| SCHEMBL16410766 | 0.69 | ACAT2 (0.47) | ACAT2 | |
| SCHEMBL16410680 | 0.67 | ACAT2 (0.37) | ACAT2 | |
| SCHEMBL16410816 | 0.66 | ACAT2 (0.45) | ACAT2 | |
| SCHEMBL16410737 | 0.66 | ACAT2 (0.35) | ACAT2 | |
| SCHEMBL16410830 | 0.66 | ACAT2 (0.57) | ACAT2 | |
| SCHEMBL16410694 | 0.66 | ACAT2 (0.47) | ACAT2 | |
| SCHEMBL16410771 | 0.65 | ACAT2 (0.40) | ACAT2 | |
| SCHEMBL16410767 | 0.65 | ACAT2 (0.43) | ACAT2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015007730-A1 | SPIROQUINOXALINE DERIVATIVES AS INHIBITORS OF NON-APOPTOTIC REGULATED CELL-DEATH | Helmholtz Zentrum München - Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH) (DE) | 2015-01-22 | — | — | WO | disclosed |