ACAT2 — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL29353066	1.00	5/20
SCHEMBL29516760	0.78	5/20
SCHEMBL16410759	0.57	4/20
SCHEMBL17757304	0.50	4/20
SCHEMBL16410830	0.57	3/20
SCHEMBL17757951	0.56	3/20
SCHEMBL17757952	0.56	3/20
SCHEMBL17757269	0.56	3/20
SCHEMBL17757973	0.54	3/20
SCHEMBL21982537	0.54	3/20
SCHEMBL17757274	0.54	3/20
SCHEMBL17757267	0.53	3/20
SCHEMBL17757279	0.50	3/20
SCHEMBL17757977	0.50	3/20
SCHEMBL17757281	0.53	2/20
SCHEMBL17757893	0.53	2/20
SCHEMBL29823199	0.53	2/20
SCHEMBL17757990	0.51	2/20
SCHEMBL17757301	0.51	2/20
SCHEMBL17757272	0.50	2/20

Clinical trials — most relevant to ACAT2 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Omega 3 and Ischemic Stroke; Fish Oil as an Option	PHASE4	UNKNOWN
The Low HDL On Six Weeks Statin Therapy (LOW) Study	PHASE4	UNKNOWN
Effects of Statin and Ezetimibe Association on Kinetics of Artificial Chilomicrons	PHASE4	COMPLETED
Overcoming Primary Resistance to Immunotherapy in Metastatic Melanoma	PHASE2	COMPLETED
Metabolic Cofactor Supplementation in Obese Patients With Non-Alcoholic Fatty Liver Disease	PHASE2	COMPLETED
The Effects of Coenzyme A Combined With Abiraterone on Patients With CRPC	PHASE1/PHASE2	UNKNOWN
Atorvastatin, L-Carnitine and Non-Alcoholic Steatohepatitis	PHASE2	UNKNOWN
Metabolic Cofactor Supplementation in Alzheimer's Disease (AD) and Parkinson's Disease (PD) Patients	PHASE2	COMPLETED
Acetylcarnitine and Insulin Sensitivity	PHASE2	COMPLETED
Ataxia-telangiectasia: Treating Mitochondrial Dysfunction With a Novel Form of Anaplerosis	PHASE2	COMPLETED
Effect of Bezafibrate on Muscle Metabolism in Patients With Fatty Acid Oxidation Defects	PHASE2	COMPLETED
Safety, Tolerability and Pharmacokinetics of Benfo-Oxythiamine (B-OT) in Healthy Volunteers	PHASE1	COMPLETED
The Effect of Glucagon on Rates of Hepatic Mitochondrial Oxidation in Man Assessed by PINTA	PHASE1	COMPLETED
Epidemiology of Atherosclerosis	nan	COMPLETED
Markers of Carnitine Acetyltransferase (CrAT) Protein Activity and Carnitine Availability	nan	COMPLETED
Development of Biomarker for Development of Non-Alcoholic Steatohepatitis (NASH) in Children	nan	WITHDRAWN
11C-Acetate PET/CT Non-FDG-Avid Tumors	nan	UNKNOWN
Lifestyle Intervention in Preparation for Pregnancy (LIPP)	nan	COMPLETED
Combining Gene Variants to Improve Risk Prediction for Metabolic (Dysfunction)- Associated Fatty Liver Disease and Its Progression to Cirrhosis in Indian Individuals With Type 2 Diabetes	nan	COMPLETED
Abnormalities in the Effects of Insulin and Exercise on Glucose- and Lipid Metabolism in Obesity and Type 2 Diabetes	nan	COMPLETED
Assessment Of Lipid Profile In Cirrhotic Patients	nan	COMPLETED
Influence of WNT4 VEZT FSHB and SIRT1 SNPs in Endometriosis: a Case Control Study of the Sardinian Population	nan	UNKNOWN
Systemic Biomarkers of Brain Injury From Hyperammonemia	nan	RECRUITING
High Fat Diet for Cardiac Metabolic Reprogramming	nan	RECRUITING
Effects of Parenteral L-carnitine Supplementation in Premature Neonates	nan	COMPLETED
The Effect Of DAAs on miRNA-122 And Insulin Resistance In Chronic HCV Patients	nan	UNKNOWN
Evaluation of Botanicals for Mechanisms Related to Appetite and Fat Metabolism	nan	COMPLETED
Hepatic Energy Fluxes in NASH and NAS Patients	nan	ACTIVE_NOT_RECRUITING
Thermogenic Silencer Regulatory Factors in Humans	nan	ACTIVE_NOT_RECRUITING
Effect of Omega-3 Fatty Acids Supplementation on Hypertriglyceridemia in Pediatric Patients With Obesity.	nan	COMPLETED

Related proteins — ESM-2 sequence neighbours (a ACAT2 binder may also engage these)

Protein	Name	Similarity
Q5XI22	—	1.000	Q5XI22 →
Q5RES5	—	0.999	Q5RES5 →
Q3T0R7	—	0.999	Q3T0R7 →
Q8CAY6	—	0.999	Q8CAY6 →
ACAA2	3-ketoacyl-CoA thiolase, mitochondrial	0.998	landscape →
P45855	—	0.994	P45855 →
P13437	—	0.994	P13437 →
P07097	—	0.993	P07097 →
P54810	—	0.991	P54810 →
P46707	—	0.989	P46707 →
P41338	—	0.989	P41338 →
Q12598	—	0.989	Q12598 →
Q0AVM3	—	0.988	Q0AVM3 →
Q8BWT1	—	0.988	Q8BWT1 →
P9WG68	—	0.988	P9WG68 →
Q5HS07	—	0.988	Q5HS07 →
Q8CQN7	—	0.988	Q8CQN7 →
P45369	—	0.987	P45369 →
P44873	—	0.987	P44873 →
P66927	—	0.987	P66927 →
A0A1D8PH52	—	0.987	A0A1D8PH52 →
P0C7L2	—	0.986	P0C7L2 →
P50174	—	0.986	P50174 →
P33291	—	0.986	P33291 →
P73825	—	0.986	P73825 →
A0R1Y7	—	0.986	A0R1Y7 →
P45363	—	0.985	P45363 →
Q9FIK7	—	0.985	Q9FIK7 →
P27796	—	0.985	P27796 →
Q04677	—	0.985	Q04677 →