Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 2/20 | 0.33 |
| ▸ | STAT6 | P42226 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.30 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16410858 | 0.81 | PIK3CA (0.35) | PIK3CAPIK3CB | |
| SCHEMBL16410629 | 0.81 | PIK3CA (0.36) | PIK3CAPIK3CB | |
| SCHEMBL17757815 | 0.79 | PIK3CB (0.37) | MAPK1STAT6LMNAPIK3CAPIK3CB | |
| SCHEMBL17757822 | 0.79 | STAT6 (0.42) | STAT6PIK3CAPIK3CB | |
| SCHEMBL16410779 | 0.76 | CYP3A4 (0.35) | — | |
| SCHEMBL16410563 | 0.76 | TP53 (0.38) | MAPK1 | |
| SCHEMBL16410672 | 0.76 | ACAT2 (0.38) | — | |
| SCHEMBL17757819 | 0.75 | PIK3CB (0.36) | MAPK1STAT6PIK3CAPIK3CB | |
| SCHEMBL16410670 | 0.74 | — | — | |
| SCHEMBL16410833 | 0.73 | CYP3A4 (0.30) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015007730-A1 | SPIROQUINOXALINE DERIVATIVES AS INHIBITORS OF NON-APOPTOTIC REGULATED CELL-DEATH | Helmholtz Zentrum München - Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH) (DE) | 2015-01-22 | — | — | WO | disclosed |