Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.36 |
| ▸ | GAA | P10253 | 5/20 | 0.35 |
| ▸ | MGAM | O43451 | 1/20 | 0.35 |
| ▸ | SI | P14410 | 1/20 | 0.35 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21098109 | 0.83 | KMT2A (0.38) | TSHRLMNAPOLBKMT2AALDH1A1 | |
| SCHEMBL16415500 | 0.81 | NR1H2 (0.43) | TSHRKMT2AALDH1A1L3MBTL1MAPT | |
| SCHEMBL16416153 | 0.79 | ATM (0.37) | TSHRLMNAPOLBKMT2AALDH1A1 | |
| SCHEMBL21639937 | 0.79 | CHRNB2 (0.33) | KMT2A | |
| SCHEMBL21798224 | 0.76 | KMT2A (0.40) | TSHRPOLBKMT2AALDH1A1GAA | |
| SCHEMBL21798169 | 0.76 | KMT2A (0.41) | TSHRLMNAPOLBKMT2AALDH1A1 | |
| SCHEMBL21798249 | 0.75 | KMT2A (0.39) | TSHRLMNAPOLBKMT2AALDH1A1 | |
| SCHEMBL29086022 | 0.74 | GAA (0.45) | TSHRPOLBKMT2AALDH1A1GAA | |
| SCHEMBL18497368 | 0.73 | TSHR (0.41) | TSHRLMNAPOLBKMT2AALDH1A1 | |
| SCHEMBL21797973 | 0.72 | POLB (0.41) | TSHRLMNAPOLBKMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015011252-A1 | PYRIMIDINE-PYRIDINONE SERINE/THREONINE KINASE INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2015-01-29 | — | — | WO | disclosed |