Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LCLAT1 | Q6UWP7 | 3/20 | 0.46 |
| ▸ | BRAF | P15056 | 4/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | FADS1 | O60427 | 1/20 | 0.41 |
| ▸ | EGFR | P00533 | 2/20 | 0.40 |
| ▸ | BTK | Q06187 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.39 |
| ▸ | ABL1 | P00519 | 1/20 | 0.39 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.39 |
| ▸ | BCR | P11274 | 1/20 | 0.39 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1640558 | 0.90 | LCLAT1 (0.45) | LCLAT1BRAFLMNASMN1; SMN2FADS1 | |
| SCHEMBL1640608 | 0.90 | BRAF (0.47) | LCLAT1BRAFLMNASMN1; SMN2FADS1 | |
| SCHEMBL1640498 | 0.88 | BRAF (0.49) | BRAFLMNASMN1; SMN2EGFRBTK | |
| SCHEMBL1642305 | 0.87 | LCLAT1 (0.43) | LCLAT1BRAFLMNASMN1; SMN2FADS1 | |
| SCHEMBL1642023 | 0.86 | LCLAT1 (0.47) | LCLAT1BRAFLMNASMN1; SMN2FADS1 | |
| SCHEMBL1640619 | 0.80 | LCLAT1 (0.49) | LCLAT1BRAFLMNASMN1; SMN2FADS1 | |
| SCHEMBL1639294 | 0.78 | BRAF (0.49) | BRAFLMNASMN1; SMN2EGFRMAPT | |
| SCHEMBL1641904 | 0.78 | BRAF (0.51) | BRAFLMNASMN1; SMN2EGFRMAPT | |
| SCHEMBL1641680 | 0.78 | BRAF (0.49) | BRAFLMNASMN1; SMN2EGFRMAPT | |
| SCHEMBL3442012 | 0.77 | SLC2A1 (0.55) | LCLAT1BRAFFADS1EGFRMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110098296-A1 | Thiazole And Oxazole Kinase Inhibitors | GLAXOSMITHKLINE LLC | 2011-04-28 | — | — | US | disclosed |
| US-20110098296-A1 | Thiazole And Oxazole Kinase Inhibitors | GLAXOSMITHKLINE LLC | 2011-04-28 | — | — | US | disclosed |
| WO-2009076140-A1 | THIAZOLE AND OXAZOLE KINASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2009-06-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110098296-A1 | Thiazole And Oxazole Kinase Inhibitors | PDXK, MAP3K1, MAP4K2 | LCLAT1 2338/4885BRAF 151/4885LMNA 3516/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.