Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 13/20 | 0.69 |
| ▸ | EGFR | P00533 | 4/20 | 0.57 |
| ▸ | ERBB2 | P04626 | 2/20 | 0.57 |
| ▸ | INSR | P06213 | 2/20 | 0.56 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.49 |
| ▸ | ABL1 | P00519 | 1/20 | 0.45 |
| ▸ | BCR | P11274 | 1/20 | 0.45 |
| ▸ | BRAF | P15056 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13815934 | 0.92 | IGF1R (0.70) | IGF1REGFRERBB2INSRHDAC1 | |
| SCHEMBL1641849 | 0.89 | IGF1R (0.56) | IGF1REGFRERBB2INSRABL1 | |
| SCHEMBL1640303 | 0.89 | IGF1R (0.55) | IGF1REGFRERBB2INSRHDAC1 | |
| SCHEMBL1641537 | 0.82 | SLC2A1 (0.55) | IGF1REGFRERBB2INSRABL1 | |
| SCHEMBL311483 | 0.82 | IGF1R (1.00) | IGF1REGFRERBB2INSRBRAF | |
| SCHEMBL1640788 | 0.81 | IGF1R (0.55) | IGF1REGFRERBB2INSRBRAF | |
| SCHEMBL310123 | 0.81 | IGF1R (0.87) | IGF1REGFRERBB2INSRBRAF | |
| SCHEMBL311177 | 0.80 | IGF1R (1.00) | IGF1REGFRERBB2INSRBRAF | |
| SCHEMBL1641944 | 0.80 | IGF1R (0.48) | IGF1REGFRERBB2INSRHDAC1 | |
| SCHEMBL1641974 | 0.80 | IGF1R (0.70) | IGF1RINSRABL1BCRBRAF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110098296-A1 | Thiazole And Oxazole Kinase Inhibitors | GLAXOSMITHKLINE LLC | 2011-04-28 | — | — | US | disclosed |
| US-20110098296-A1 | Thiazole And Oxazole Kinase Inhibitors | GLAXOSMITHKLINE LLC | 2011-04-28 | — | — | US | disclosed |
| US-20110098296-A1 | Thiazole And Oxazole Kinase Inhibitors | GLAXOSMITHKLINE LLC | 2011-04-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110098296-A1 | Thiazole And Oxazole Kinase Inhibitors | PDXK, MAP3K1, MAP4K2 | IGF1R 396/4885EGFR 478/4885ERBB2 69/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.