Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR1 | P21554 | 4/20 | 0.49 |
| ▸ | CNR2 | P34972 | 3/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | DPP4 | P27487 | 1/20 | 0.47 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.46 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.45 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.45 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.45 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.45 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.45 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.45 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.45 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 3/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | NAMPT | P43490 | 2/20 | 0.43 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16420402 | 0.92 | POLB (0.51) | CNR1CNR2POLBDPP4ADRA1A | |
| SCHEMBL16420913 | 0.87 | POLB (0.53) | CNR1CNR2POLBDPP4ADRA1A | |
| SCHEMBL16418429 | 0.87 | CNR1 (0.47) | CNR1CNR2POLBADRA1AOPRM1 | |
| SCHEMBL15202851 | 0.80 | OPRM1 (0.54) | POLBDPP4ADRA1AOPRM1SLC22A1 | |
| SCHEMBL9064765 | 0.80 | CHRM5 (0.64) | ADRA1AOPRM1SLC22A1SLC6A4OPRD1 | |
| SCHEMBL16418428 | 0.79 | POLB (0.48) | CNR1CNR2POLBDPP4ADRA1A | |
| SCHEMBL14000285 | 0.77 | POLB (0.68) | POLBDPP4ADRA1AOPRM1SLC22A1 | |
| SCHEMBL16420945 | 0.76 | DPP4 (0.50) | CNR1CNR2POLBDPP4ADRA1A | |
| SCHEMBL16420923 | 0.76 | DPP4 (0.47) | CNR1CNR2POLBDPP4ADRA1A | |
| SCHEMBL22528304 | 0.75 | HTT (0.46) | CNR1CNR2POLBOPRM1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2814828-B9 | PERIPHERALLY RESTRICTED DIPHENYL PURINE DERIVATIVES | RES TRIANGLE INST (US) | 2020-10-07 | — | — | EP | disclosed |
| US-9458160-B2 | Peripherally restricted diphenyl purine derivatives | RESEARCH TRIANGLE INSTITUTE (US) | 2016-10-04 | — | — | US | disclosed |
| US-20160046630-A1 | PERIPHERALLY RESTRICTED DIPHENYL PURINE DERIVATIVES | RES TRIANGLE INST (US) | 2016-02-18 | — | — | US | disclosed |
| US-9187480-B2 | Peripherally restricted diphenyl purine derivatives | RESEARCH TRIANGLE INSTITUTE (US) | 2015-11-17 | — | — | US | disclosed |
| US-20150031689-A1 | PERIPHERALLY RESTRICTED DIPHENYL PURINE DERIVATIVES | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2015-01-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150031689-A1 | PERIPHERALLY RESTRICTED DIPHENYL PURINE DERIVATIVES | CNR1, CNR2, P2RY1 | CNR1 1/4885CNR2 2/4885POLB 860/4885 |
| US-20160046630-A1 | PERIPHERALLY RESTRICTED DIPHENYL PURINE DERIVATIVES | CNR1, CNR2, P2RY1 | CNR1 1/4885CNR2 2/4885POLB 860/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.