Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 6/20 | 0.35 |
| ▸ | EGFR | P00533 | 2/20 | 0.35 |
| ▸ | ERBB2 | P04626 | 2/20 | 0.35 |
| ▸ | IGF1R | P08069 | 2/20 | 0.35 |
| ▸ | CDK19 | Q9BWU1 | 2/20 | 0.35 |
| ▸ | SYK | P43405 | 2/20 | 0.35 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.35 |
| ▸ | CCNT1 | O60563 | 3/20 | 0.35 |
| ▸ | CDK2 | P24941 | 3/20 | 0.35 |
| ▸ | CDK9 | P50750 | 3/20 | 0.35 |
| ▸ | CDK1 | P06493 | 2/20 | 0.35 |
| ▸ | CCNB1 | P14635 | 2/20 | 0.35 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.35 |
| ▸ | CDK7 | P50613 | 2/20 | 0.35 |
| ▸ | CCNH | P51946 | 2/20 | 0.35 |
| ▸ | CCNA1 | P78396 | 2/20 | 0.35 |
| ▸ | AURKA | O14965 | 2/20 | 0.34 |
| ▸ | CAMK2D | Q13557 | 1/20 | 0.34 |
| ▸ | ABL1 | P00519 | 1/20 | 0.34 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL1642084 | 0.83 | ABL1 (0.40) | BRAFEGFRERBB2IGF1RCDK19 | |
| SCHEMBL12726574 | 0.82 | ABL1 (0.43) | BRAFEGFRERBB2IGF1RCDK19 | |
| SCHEMBL1641958 | 0.79 | IGF1R (0.51) | BRAFEGFRERBB2IGF1RCDK19 | |
| SCHEMBL1640516 | 0.72 | EGFR (0.43) | BRAFEGFRERBB2IGF1RCDK19 | |
| SCHEMBL12726216 | 0.69 | BRAF (0.52) | BRAFEGFRERBB2IGF1RCDK19 | |
| SCHEMBL1641059 | 0.69 | IGF1R (0.45) | BRAFEGFRERBB2IGF1RCDK19 | |
| SCHEMBL12726561 | 0.67 | BRAF (0.54) | BRAFEGFRERBB2IGF1RCDK19 | |
| SCHEMBL12726565 | 0.67 | IGF1R (0.59) | BRAFEGFRERBB2IGF1RCDK19 | |
| SCHEMBL1641705 | 0.67 | SLC2A1 (0.51) | BRAFEGFRERBB2IGF1RABL1 | |
| Formic Acid SCHEMBL1641061 | 0.65 | IGF1R (0.56) | BRAFEGFRERBB2IGF1RCDK19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110098296-A1 | Thiazole And Oxazole Kinase Inhibitors | GLAXOSMITHKLINE LLC | 2011-04-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110098296-A1 | Thiazole And Oxazole Kinase Inhibitors | PDXK, MAP3K1, MAP4K2 | BRAF 151/4885EGFR 478/4885ERBB2 69/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.