Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAF1 | P04049 | 10/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | BRAF | P15056 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | KDR | P35968 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL379265 | 1.00 | RAF1 (0.46) | RAF1POLBMAPK14KDM4EHPGD | |
| SCHEMBL379266 | 1.00 | RAF1 (0.46) | RAF1POLBMAPK14KDM4EHPGD | |
| SCHEMBL4534203 | 0.85 | RAF1 (0.47) | RAF1POLBMAPK14KDM4EHPGD | |
| SCHEMBL4534200 | 0.85 | RAF1 (0.47) | RAF1POLBMAPK14KDM4EHPGD | |
| SCHEMBL27145420 | 0.85 | RAF1 (0.47) | RAF1POLBMAPK14KDM4EHPGD | |
| SCHEMBL15229756 | 0.83 | RAF1 (0.47) | RAF1POLBMAPK14KDM4EHPGD | |
| SCHEMBL28799154 | 0.83 | RAF1 (0.47) | RAF1POLBMAPK14KDM4EHPGD | |
| SCHEMBL379165 | 0.83 | RAF1 (0.47) | RAF1POLBMAPK14KDM4EHPGD | |
| SCHEMBL30667504 | 0.83 | RAF1 (0.47) | RAF1POLBMAPK14KDM4EHPGD | |
| SCHEMBL31686438 | 0.83 | RAF1 (0.51) | RAF1POLBMAPK14KDM4EHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-RE49897-E1 | Salts of a dihydroquinazoline derivative | AIC246 AG & CO. KG (DE) | 2024-04-02 | — | — | US | disclosed |
| US-10603384-B2 | Pharmaceutical composition containing an antivirally active dihydroquinazoline derivative | AICURIS GMBH & CO. KG (DE) | 2020-03-31 | — | — | US | disclosed |
| EP-3556350-A1 | PHARMACEUTICAL PREPARATION COMPRISING AN ANTIVIRAL DIHYDROQUINAZOLINE DERIVATIVE WITH S CONFIGURATION IN POSITION 4 | AiCuris Anti-infective Cures GmbH (DE) | 2019-10-23 | — | — | EP | disclosed |
| US-10287254-B2 | Salts of a dihydroquinazoline derivative | AICURIS GMBH & CO. KG (DE) | 2019-05-14 | — | — | US | disclosed |
| US-20170362186-A1 | Salts of a dihydroquinazoline derivative | AICURIS GMBH & CO. KG (DE) | 2017-12-21 | — | — | US | disclosed |
| US-9637459-B2 | Sodium and calcium salts of dihydroquinazoline derivative and use thereof as antiviral agents | AICURIS GMBH & CO KG. (DE) | 2017-05-02 | — | — | US | disclosed |
| US-20170114026-A1 | Salts of a dihydroquinazoline derivative | AICURIS GMBH & CO. KG (DE) | 2017-04-27 | — | — | US | disclosed |
| US-9512085-B2 | Salts of a dihydroquinazoline derivative | AICURIS GMBH & CO. KG (DE) | 2016-12-06 | — | — | US | disclosed |
| US-20150133461-A1 | PHARMACEUTICAL COMPOSITION CONTAINING AN ANTIVIRALLY ACTIVE DIHYDROQUINAZOLINE DERIVATIVE | AICURIS GMBH & CO. KG (DE) | 2015-05-14 | — | — | US | disclosed |
| US-20150045371-A1 | Salts of a dihydroquinazoline derivative | AICURIS GMBH & CO. KG (DE) | 2015-02-12 | — | — | US | disclosed |
| US-20150038514-A1 | SODIUM AND CALCIUM SALTS OF DIHYDROQUINAZOLINE DERIVATIVE AND USE THEREOF AS ANTIVIRAL AGENTS | AIC246 AG & CO. KG (DE) | 2015-02-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170114026-A1 | Salts of a dihydroquinazoline derivative | BAD, VHL, EIF2AK2 | RAF1 1621/4885POLB 1596/4885MAPK14 1613/4885 |
| US-20150038514-A1 | SODIUM AND CALCIUM SALTS OF DIHYDROQUINAZOLINE DERIVATIVE AND USE THEREOF AS ANTIVIRAL AGENTS | CACNA1I, CACNA1F, CACNA1S | RAF1 3133/4885POLB 3430/4885MAPK14 598/4885 |
| US-20150133461-A1 | PHARMACEUTICAL COMPOSITION CONTAINING AN ANTIVIRALLY ACTIVE DIHYDROQUINAZOLINE DERIVATIVE | RPL5, EIF2AK2, RPL35 | RAF1 3984/4885POLB 2249/4885MAPK14 2886/4885 |
| US-10287254-B2 | Salts of a dihydroquinazoline derivative | BAD, IRF3, VHL | RAF1 1783/4885POLB 1608/4885MAPK14 1177/4885 |
| US-20170362186-A1 | Salts of a dihydroquinazoline derivative | BAD, CHUK, EIF2AK2 | RAF1 2739/4885POLB 1593/4885MAPK14 1476/4885 |
| US-20150045371-A1 | Salts of a dihydroquinazoline derivative | BAD, CHUK, EIF2AK2 | RAF1 2739/4885POLB 1593/4885MAPK14 1476/4885 |
| US-10603384-B2 | Pharmaceutical composition containing an antivirally active dihydroquinazoline derivative | RPL5, EIF2AK2, RPL35 | RAF1 3984/4885POLB 2249/4885MAPK14 2886/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.