Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAF1 | P04049 | 10/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | BRAF | P15056 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | KDR | P35968 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16428166 | 1.00 | RAF1 (0.46) | RAF1POLBMAPK14KDM4EHPGD | |
| SCHEMBL379266 | 1.00 | RAF1 (0.46) | RAF1POLBMAPK14KDM4EHPGD | |
| SCHEMBL4534203 | 0.85 | RAF1 (0.47) | RAF1POLBMAPK14KDM4EHPGD | |
| SCHEMBL4534200 | 0.85 | RAF1 (0.47) | RAF1POLBMAPK14KDM4EHPGD | |
| SCHEMBL27145420 | 0.85 | RAF1 (0.47) | RAF1POLBMAPK14KDM4EHPGD | |
| SCHEMBL15229756 | 0.83 | RAF1 (0.47) | RAF1POLBMAPK14KDM4EHPGD | |
| SCHEMBL28799154 | 0.83 | RAF1 (0.47) | RAF1POLBMAPK14KDM4EHPGD | |
| SCHEMBL379165 | 0.83 | RAF1 (0.47) | RAF1POLBMAPK14KDM4EHPGD | |
| SCHEMBL30667504 | 0.83 | RAF1 (0.47) | RAF1POLBMAPK14KDM4EHPGD | |
| SCHEMBL31686438 | 0.83 | RAF1 (0.51) | RAF1POLBMAPK14KDM4EHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1893587-B1 | METHOD FOR PRODUCING DIHYDROQUINAZOLINES | AICURIS GMBH & CO KG (DE) | 2012-01-25 | — | — | EP | claimed |
| US-8084604-B2 | Process for the preparation of dihydroquinazolines | Aicuris GmbH & Co., KG (DE) | 2011-12-27 | — | — | US | claimed |
| US-8084604-B2 | Process for the preparation of dihydroquinazolines | Aicuris GmbH & Co., KG (DE) | 2011-12-27 | — | — | US | disclosed |