Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PAK4 | O96013 | 5/20 | 0.40 |
| ▸ | PIKFYVE | Q9Y2I7 | 1/20 | 0.40 |
| ▸ | MAP3K14 | Q99558 | 7/20 | 0.35 |
| ▸ | PRKD1 | Q15139 | 2/20 | 0.35 |
| ▸ | TTBK1 | Q5TCY1 | 5/20 | 0.32 |
| ▸ | TTBK2 | Q6IQ55 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11970667 | 0.86 | PAK4 (0.47) | PAK4PIKFYVEMAP3K14PRKD1TTBK1 | |
| SCHEMBL11970779 | 0.79 | PAK4 (0.47) | PAK4PIKFYVEMAP3K14PRKD1TTBK1 | |
| SCHEMBL12001600 | 0.77 | TTBK1 (0.38) | PAK4PIKFYVEMAP3K14TTBK1TTBK2 | |
| SCHEMBL11970536 | 0.76 | PAK4 (0.54) | PAK4PIKFYVEMAP3K14PRKD1TTBK1 | |
| SCHEMBL11970583 | 0.76 | PAK4 (0.55) | PAK4PIKFYVEMAP3K14PRKD1 | |
| SCHEMBL11971098 | 0.72 | PAK4 (0.54) | PAK4PIKFYVEMAP3K14PRKD1TTBK1 | |
| SCHEMBL11970266 | 0.72 | PAK4 (0.50) | PAK4PIKFYVEMAP3K14PRKD1TTBK1 | |
| SCHEMBL11971083 | 0.72 | PAK4 (0.50) | PAK4PIKFYVEMAP3K14PRKD1TTBK1 | |
| SCHEMBL11970755 | 0.72 | PAK4 (0.50) | PAK4PIKFYVEMAP3K14PRKD1TTBK1 | |
| SCHEMBL11970969 | 0.72 | PAK4 (0.50) | PAK4PIKFYVEMAP3K14PRKD1TTBK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20150038460-A1 | 6,5-Heterocyclic Propargylic Alcohol Compounds and Uses Therefor | GENENTECH, INC. (US) | 2015-02-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150038460-A1 | 6,5-Heterocyclic Propargylic Alcohol Compounds and Uses Therefor | NFKB1, NFRKB, NFKBIA | PAK4 1856/4885PIKFYVE 3647/4885MAP3K14 519/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.