Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | GCK | P35557 | 1/20 | 0.33 |
| ▸ | PIK3CD | O00329 | 3/20 | 0.32 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.32 |
| ▸ | PIK3CG | P48736 | 3/20 | 0.32 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.32 |
| ▸ | MTOR | P42345 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | USP2 | O75604 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | CASP3 | P42574 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1330623 | 0.73 | GCK (0.61) | SMN1; SMN2GCKMEN1NPC1USP2 | |
| SCHEMBL1329480 | 0.61 | GCK (0.51) | GRM5SMN1; SMN2GCKMEN1NPC1 | |
| Hydrochloric Acid SCHEMBL1330742 | 0.61 | GCK (0.50) | GRM5SMN1; SMN2GCKMEN1NPC1 | |
| SCHEMBL6136798 | 0.60 | ALDH1A1 (0.46) | SMN1; SMN2PIK3CDMEN1ALDH1A1POLB | |
| SCHEMBL2239504 | 0.58 | CA12 (0.58) | SMN1; SMN2ALDH1A1HSD17B10RETKIF5B | |
| SCHEMBL31281467 | 0.58 | CA12 (0.58) | SMN1; SMN2ALDH1A1HSD17B10RETKIF5B | |
| SCHEMBL7938044 | 0.58 | SMN1; SMN2 (0.47) | SMN1; SMN2PIK3CAMTORNPC1ALDH1A1 | |
| SCHEMBL1328903 | 0.58 | GCK (0.62) | SMN1; SMN2GCKMEN1NPC1ALDH1A1 | |
| SCHEMBL1329648 | 0.57 | GCK (0.60) | GCKMEN1NPC1GAARAB9A | |
| SCHEMBL1328821 | 0.56 | GCK (0.56) | GCKMEN1NPC1GAARAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2543667-B1 | A method of preparing 2-aminopyridine analogs as glucokinase activators | ARRAY BIOPHARMA INC (US) | 2015-01-28 | — | — | EP | disclosed |