Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SUV39H2 | Q9H5I1 | 2/20 | 0.40 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.38 |
| ▸ | CDK9 | P50750 | 1/20 | 0.38 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.36 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.36 |
| ▸ | BTK | Q06187 | 3/20 | 0.35 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.35 |
| ▸ | PIK3R1 | P27986 | 2/20 | 0.35 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.35 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.35 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.35 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.34 |
| ▸ | GCK | P35557 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | DHODH | Q02127 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18330519 | 0.81 | SUV39H2 (0.44) | SUV39H2CCNT1CDK9PDE3BPDE3A | |
| SCHEMBL26062785 | 0.74 | CCNT1 (0.41) | SUV39H2CCNT1CDK9PDE3BPDE3A | |
| SCHEMBL28686966 | 0.72 | EP300 (0.44) | SUV39H2CCNT1CDK9PIK3CDPIK3R1 | |
| SCHEMBL21706106 | 0.69 | ALDH1A1 (0.42) | SUV39H2PDE3BPDE3APIK3CDPIK3CA | |
| SCHEMBL19318456 | 0.69 | EGFR (0.50) | ALDH1A1DHODHSMN1; SMN2LMNAMAPT | |
| SCHEMBL8357955 | 0.69 | HSP90AA1 (0.44) | PDE3BPDE3ABTKPIK3CDPIK3CA | |
| SCHEMBL17548211 | 0.69 | SUV39H2 (0.46) | SUV39H2CCNT1CDK9PDE3BPDE3A | |
| SCHEMBL20764947 | 0.69 | TDP1 (0.38) | SUV39H2CCNT1CDK9PDE3BPDE3A | |
| SCHEMBL30439702 | 0.69 | TDP1 (0.38) | SUV39H2CCNT1CDK9PDE3BPDE3A | |
| SCHEMBL20795222 | 0.67 | CCNT1 (0.35) | SUV39H2CCNT1CDK9PDE3BPDE3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10005774-B2 | Syk inhibitors | GILEAD SCIENCES, INC. (US) | 2018-06-26 | — | — | US | disclosed |
| US-10005774-B2 | Syk inhibitors | GILEAD SCIENCES, INC. (US) | 2018-06-26 | — | — | US | disclosed |
| US-20160368918-A1 | SYK INHIBITORS | Kronos Bio, Inc. | 2016-12-22 | — | — | US | disclosed |
| US-9376441-B2 | Substituted pyrrolidines as SYK inhibitors | GILEAD SCIENCES, INC. (US) | 2016-06-28 | — | — | US | disclosed |
| US-20150038488-A1 | SYK INHIBITORS | Kronos Bio, Inc. | 2015-02-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150038488-A1 | SYK INHIBITORS | SYK, BTK, LYN | SUV39H2 2411/4885CCNT1 2281/4885CDK9 909/4885 |
| US-20160368918-A1 | SYK INHIBITORS | SYK, BTK, LYN | SUV39H2 2551/4885CCNT1 2171/4885CDK9 904/4885 |
| US-10005774-B2 | Syk inhibitors | SYK, BTK, LYN | SUV39H2 2551/4885CCNT1 2171/4885CDK9 904/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.