Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH2 | P25021 | 2/20 | 0.49 |
| ▸ | HTR5A | P47898 | 1/20 | 0.49 |
| ▸ | HTR2B | P41595 | 15/20 | 0.40 |
| ▸ | P2RY1 | P47900 | 4/20 | 0.40 |
| ▸ | HTR2C | P28335 | 12/20 | 0.40 |
| ▸ | ADORA1 | P30542 | 10/20 | 0.40 |
| ▸ | TMIGD3 | P0DMS9 | 7/20 | 0.40 |
| ▸ | ADORA2A | P29274 | 6/20 | 0.40 |
| ▸ | P2RY2 | P41231 | 2/20 | 0.40 |
| ▸ | ADORA3 | P0DMS8 | 5/20 | 0.39 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.39 |
| ▸ | TSPO | P30536 | 1/20 | 0.38 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.38 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.38 |
| ▸ | HTR1D | P28221 | 1/20 | 0.38 |
| ▸ | HTR2A | P28223 | 1/20 | 0.38 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16440583 | 0.92 | P2RY1 (0.50) | HRH2HTR5AHTR2BP2RY1HTR2C | |
| SCHEMBL16440571 | 0.85 | HRH2 (0.49) | HRH2HTR5AHTR2BP2RY1HTR2C | |
| SCHEMBL12269853 | 0.83 | ADORA3 (0.45) | HRH2HTR5AP2RY1ADORA2AP2RY2 | |
| SCHEMBL19799166 | 0.82 | HRH2 (0.49) | HRH2HTR5AHTR2BP2RY1HTR2C | |
| SCHEMBL19459932 | 0.82 | HRH2 (0.49) | HRH2HTR5AHTR2BP2RY1HTR2C | |
| SCHEMBL12269794 | 0.82 | HTR2B (0.55) | HRH2HTR5AHTR2BHTR2CADORA1 | |
| SCHEMBL19415065 | 0.82 | HTR2B (0.55) | HRH2HTR5AHTR2BHTR2CADORA1 | |
| SCHEMBL12269764 | 0.81 | HRH2 (0.49) | HRH2HTR5AHTR2BP2RY1HTR2C | |
| SCHEMBL12269789 | 0.80 | HRH2 (0.48) | HRH2HTR5AHTR2BP2RY1HTR2C | |
| SCHEMBL19415074 | 0.80 | HRH2 (0.48) | HRH2HTR5AHTR2BP2RY1HTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9526739-B2 | Compositions and methods to treat cardiac diseases | UNIVERSITY OF CONNECTICUT (US) | 2016-12-27 | — | — | US | disclosed |
| US-20160166591-A1 | COMPOSITIONS AND METHODS TO TREAT CARDIAC DISEASES | GOOGLE LLC | 2016-06-16 | — | — | US | disclosed |
| US-9303053-B2 | Compositions and methods to treat cardiac diseases | UNIVERSITY OF CONNECTICUT (US) | 2016-04-05 | — | — | US | disclosed |
| US-20150038463-A1 | COMPOSITIONS AND METHODS TO TREAT CARDIAC DISEASES | UNIV CONNECTICUT (US) | 2015-02-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150038463-A1 | COMPOSITIONS AND METHODS TO TREAT CARDIAC DISEASES | P2RY12, P2RX6, P2RY14 | HRH2 1177/4885HTR5A 688/4885HTR2B 1733/4885 |
| US-20160166591-A1 | COMPOSITIONS AND METHODS TO TREAT CARDIAC DISEASES | P2RY12, P2RX6, P2RY14 | HRH2 1177/4885HTR5A 688/4885HTR2B 1733/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.