Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 3/20 | 0.57 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.57 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.57 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.49 |
| ▸ | CGAS | Q8N884 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.43 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.43 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.43 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.43 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.43 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16158535 | 0.81 | CYP19A1 (0.52) | CYP19A1CYP11B1CYP11B2AAK1CGAS | |
| SCHEMBL28004650 | 0.80 | CYP19A1 (0.66) | CYP19A1CYP11B1CYP11B2AAK1CGAS | |
| SCHEMBL9290092 | 0.80 | CYP11B1 (0.61) | CYP19A1CYP11B1CYP11B2AAK1CGAS | |
| SCHEMBL11084791 | 0.80 | TP53 (0.44) | CYP19A1CYP11B1CYP11B2MEN1KMT2A | |
| SCHEMBL6127820 | 0.79 | CYP11B1 (0.53) | CYP19A1CYP11B1CYP11B2AAK1CGAS | |
| SCHEMBL4849093 | 0.79 | CYP11B1 (0.60) | CYP19A1CYP11B1CYP11B2AAK1CGAS | |
| SCHEMBL27159848 | 0.79 | CYP11B1 (0.60) | CYP19A1CYP11B1CYP11B2AAK1CGAS | |
| SCHEMBL1037506 | 0.79 | CYP11B1 (0.60) | CYP19A1CYP11B1CYP11B2AAK1CGAS | |
| SCHEMBL16437249 | 0.77 | CYP11B1 (0.57) | CYP19A1CYP11B1CYP11B2AAK1CGAS | |
| SCHEMBL8738604 | 0.77 | CYP19A1 (0.57) | CYP19A1CYP11B1CYP11B2AAK1CGAS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015017610-A1 | SYK INHIBITORS | GILEAD SCIENCES, INC. (US) | 2015-02-05 | — | — | WO | disclosed |