Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B1 | P15538 | 2/20 | 0.60 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.60 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.60 |
| ▸ | IDO1 | P14902 | 3/20 | 0.56 |
| ▸ | CGAS | Q8N884 | 1/20 | 0.54 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.49 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.48 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.44 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.44 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.44 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.44 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.44 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11702033 | 0.88 | IDO1 (0.60) | CYP11B1CYP11B2CYP19A1IDO1CGAS | |
| SCHEMBL28004650 | 0.83 | CYP19A1 (0.66) | CYP11B1CYP11B2CYP19A1CGASAAK1 | |
| SCHEMBL9290092 | 0.83 | CYP11B1 (0.61) | CYP11B1CYP11B2CYP19A1IDO1CGAS | |
| SCHEMBL1037506 | 0.81 | CYP11B1 (0.60) | CYP11B1CYP11B2CYP19A1IDO1CGAS | |
| SCHEMBL27159848 | 0.81 | CYP11B1 (0.60) | CYP11B1CYP11B2CYP19A1IDO1CGAS | |
| SCHEMBL8738604 | 0.79 | CYP19A1 (0.57) | CYP11B1CYP11B2CYP19A1CGASAAK1 | |
| SCHEMBL16441978 | 0.79 | CYP19A1 (0.57) | CYP11B1CYP11B2CYP19A1CGASAAK1 | |
| SCHEMBL16437249 | 0.79 | CYP11B1 (0.57) | CYP11B1CYP11B2CYP19A1CGASAAK1 | |
| SCHEMBL16983194 | 0.79 | IDO1 (0.61) | CYP11B1CYP11B2CYP19A1IDO1CGAS | |
| SCHEMBL6334824 | 0.78 | IDO1 (0.65) | CYP11B1CYP11B2CYP19A1IDO1CGAS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7456169-B2 | Heterocyclic kinase inhibitors | ABBOTT LABORATORIES INC. (US) | 2008-11-25 | — | — | US | disclosed |
| US-20070254867-A1 | Heterocyclic Kinase Inhibitors | ABBVIE INC. | 2007-11-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070254867-A1 | Heterocyclic Kinase Inhibitors | MAP3K20, MAP3K19, MAP4K2 | CYP11B1 2685/4885CYP11B2 2636/4885CYP19A1 1766/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.