Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.60 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.60 |
| ▸ | AKT1 | P31749 | 3/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | CTSL | P07711 | 2/20 | 0.44 |
| ▸ | CTSB | P07858 | 2/20 | 0.44 |
| ▸ | CTSS | P25774 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | CA12 | O43570 | 1/20 | 0.40 |
| ▸ | CA1 | P00915 | 1/20 | 0.40 |
| ▸ | CA7 | P43166 | 1/20 | 0.40 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.40 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL440962 | 0.84 | AKT1 (0.49) | HSP90AA1HSP90AB1AKT1ALDH1A1CTSL | |
| SCHEMBL12192239 | 0.84 | HSP90AA1 (0.68) | HSP90AA1HSP90AB1ALDH1A1MAPTMEN1 | |
| SCHEMBL13042435 | 0.83 | HSP90AA1 (0.71) | HSP90AA1HSP90AB1AKT1ALDH1A1MAPT | |
| SCHEMBL13380813 | 0.79 | HSP90AA1 (0.74) | HSP90AA1HSP90AB1ALDH1A1MAPTMEN1 | |
| SCHEMBL12808730 | 0.79 | HSP90AA1 (0.74) | HSP90AA1HSP90AB1ALDH1A1MAPTMEN1 | |
| SCHEMBL14292293 | 0.78 | HSP90AA1 (0.59) | HSP90AA1HSP90AB1ALDH1A1MAPTMEN1 | |
| SCHEMBL12192354 | 0.76 | HSP90AA1 (0.70) | HSP90AA1HSP90AB1ALDH1A1MAPTMEN1 | |
| Elesclomol SCHEMBL313745 | 0.76 | HSP90AA1 (1.00) | HSP90AA1HSP90AB1ALDH1A1MAPTMEN1 | |
| SCHEMBL12154023 | 0.76 | HSP90AA1 (0.70) | HSP90AA1HSP90AB1ALDH1A1MAPTNPC1 | |
| SCHEMBL27733374 | 0.76 | HSP90AA1 (0.70) | HSP90AA1HSP90AB1ALDH1A1MAPTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8633323-B2 | Process for preparing bis(thiohydrazide amides) | SYNTA PHARMACEUTICALS CORP. (US) | 2014-01-21 | — | — | US | disclosed |
| US-8633323-B2 | Process for preparing bis(thiohydrazide amides) | SYNTA PHARMACEUTICALS CORP. (US) | 2014-01-21 | — | — | US | disclosed |
| US-20110098476-A1 | PROCESS FOR PREPARING BIS(THIOHYDRAZIDE AMIDES) | SYNTA PHARMACEUTICALS CORP. | 2011-04-28 | — | — | US | disclosed |
| US-20110098476-A1 | PROCESS FOR PREPARING BIS(THIOHYDRAZIDE AMIDES) | SYNTA PHARMACEUTICALS CORP. | 2011-04-28 | — | — | US | disclosed |
| WO-2009123704-A2 | PROCESS FOR PREPARING BIS(THIOHYDRAZIDE AMIDES) | SYNTA PHARMACEUTICALS CORP. (US) | 2009-10-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110098476-A1 | PROCESS FOR PREPARING BIS(THIOHYDRAZIDE AMIDES) | H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16, H1-3, CYB5R3 | HSP90AA1 2929/4885HSP90AB1 2572/4885AKT1 3931/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.