CYB5R3

NADH-cytochrome b5 reductase · P00387 · CYB5R3 on Sugi Atlas →

88 patent compounds predicted against CYB5R3, 73 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
Benzylthiouracil (SCHEMBL815137)	0.59	3/20
SCHEMBL9878921	0.54	3/20
SCHEMBL23160962	0.50	3/20
SCHEMBL5907178	0.49	3/20
SCHEMBL14123256	0.49	3/20
SCHEMBL11736412	0.47	3/20
SCHEMBL11741161	0.47	3/20
SCHEMBL10489669	0.46	3/20
SCHEMBL23306692	0.46	3/20
SCHEMBL21328426	0.45	3/20
Propylthiouracil (SCHEMBL28148345)	0.45	3/20
Propylthiouracil (SCHEMBL28149476)	0.45	3/20
SCHEMBL11581683	0.44	3/20
SCHEMBL11582466	0.41	3/20
SCHEMBL16402710	0.40	3/20
SCHEMBL29955654	0.40	3/20
SCHEMBL5673306	0.39	3/20
Propylthiouracil (SCHEMBL5493721)	0.38	3/20
Propylthiouracil (SCHEMBL9443756)	0.37	3/20
Propylthiouracil (SCHEMBL5493725)	0.36	3/20

Clinical trials — most relevant to CYB5R3 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
COMS for Chronic Ulcers Treatment	PHASE4	RECRUITING
Pharmacogenetics of Nicotine Addiction Treatment	PHASE3	COMPLETED
Nicotinamide Riboside on Mitochondrial Function in Li-Fraumeni Syndrome	PHASE1/PHASE2	COMPLETED
Activity of Regorafenib in Combination With Chemotherapy in Patients With Advanced Biliary Tract Cancer	PHASE1/PHASE2	COMPLETED
IST Neoadjuvant Abraxane in Newly Diagnosed Breast Cancer	PHASE2	UNKNOWN
Nitrites, Skeletal Muscle Mitochondrial Bioenergetics, and Physical Activity in Old Age	PHASE2	COMPLETED
Base Editing for Mutation Repair in Hematopoietic Stem & Progenitor Cells for X-Linked Chronic Granulomatous Disease	PHASE1/PHASE2	RECRUITING
Trial of Nicotinamide Riboside and Co-enzyme Q10 in Chronic Kidney Disease	PHASE2	COMPLETED
Study of Gene Therapy Using a Lentiviral Vector to Treat X-linked Chronic Granulomatous Disease	PHASE1/PHASE2	COMPLETED
Effects of Nicotinamide Riboside on Bioenergetics and Oxidative Stress in Mild Cognitive Impairment/Alzheimer's Dementia	EARLY_PHASE1	ACTIVE_NOT_RECRUITING
SWOG 8897-A DNA Analysis in Predicting Treatment Outcome in Women With Breast Cancer in SWOG 8897	nan	COMPLETED
Plasma Cytochrome c as Biomarker of Traumatic Injury and Predictor of Outcome	nan	COMPLETED
Ataxia-telangiectasia: Treating Mitochondrial Dysfunction With Nicotinamide Riboside	nan	UNKNOWN
Immunological Profile and Clinical Characteristics of Children Diagnosed With Chronic Granulomatous Disease	nan	UNKNOWN
Nicotinamide Riboside and Mitochondrial Biogenesis	nan	COMPLETED
Tissue Sample Study for Mitochondrial Disorders	nan	ENROLLING_BY_INVITATION
Parkinson's Diseases Susceptibility Genes and Pesticides	nan	COMPLETED
Pharmacogenetic Determinants Of Treatment Response In Children	nan	RECRUITING
A Feasibility Study: Assessing Photobiomodulation in Myalgic Encephalomyelitis	nan	UNKNOWN
Nutritional Assessment in Patient of Mucopolysaccharide	nan	NOT_YET_RECRUITING
Relationship Between Mitochondrial Dysfunction and Fatique in Cancer Patients Following External Beam Radiation Therapy	nan	COMPLETED
Factors Affecting Post-transplant Cyclophosphamide (PTCy) Efficacy	nan	RECRUITING
Cyclophosphamide in Lupus Nephritis	nan	UNKNOWN
Genetic Mechanisms of Chronic Obstructive Pulmonary Disease (COPD)	nan	COMPLETED
Forced Oscillometry in Infants With Bronchopulmonary Dysplasia	nan	RECRUITING
Pharmacogenomics of Antidepressant Response in Children and Adolescents	nan	COMPLETED
Role of Nox2 in CNI-induced Renal Fibrosis	nan	COMPLETED
Nicotinamide Riboside in Ulcerative Colitis	nan	RECRUITING
Universal Rare Gene Study: A Registry and Natural History Study of Retinal Dystrophies Associated With Rare Disease-Causing Genetic Variants	nan	RECRUITING
NCF Gene & TNFSF4 in SLE Patients	nan	UNKNOWN

Related proteins — ESM-2 sequence neighbours (a CYB5R3 binder may also engage these)

Protein	Name	Similarity
Q60HG4	—	1.000	Q60HG4 →
P07514	—	1.000	P07514 →
P20070	—	1.000	P20070 →
Q9DCN2	—	0.999	Q9DCN2 →
Q0X0E5	—	0.998	Q0X0E5 →
P83686	—	0.996	P83686 →
Q6BCY4	—	0.996	Q6BCY4 →
Q3KNK3	—	0.993	Q3KNK3 →
Q9UHQ9	—	0.992	Q9UHQ9 →
Q6AY12	—	0.989	Q6AY12 →
Q5BJ68	—	0.989	Q5BJ68 →
Q0P487	—	0.989	Q0P487 →
A2QCV4	—	0.989	A2QCV4 →
Q5ZHX7	—	0.988	Q5ZHX7 →
Q5PQA4	—	0.987	Q5PQA4 →
Q0CY37	—	0.987	Q0CY37 →
Q1DWN4	—	0.987	Q1DWN4 →
Q2UFN3	—	0.986	Q2UFN3 →
Q9ZNT1	—	0.986	Q9ZNT1 →
A1DHW1	—	0.985	A1DHW1 →
Q4X0B5	—	0.985	Q4X0B5 →
A4R935	—	0.984	A4R935 →
Q54NC1	—	0.984	Q54NC1 →
Q6CA86	—	0.984	Q6CA86 →
P0CP15	—	0.983	P0CP15 →
Q4PGW7	—	0.983	Q4PGW7 →
Q3SYT8	—	0.983	Q3SYT8 →
Q5AZB4	—	0.983	Q5AZB4 →
O74557	—	0.983	O74557 →
Q6BUX2	—	0.982	Q6BUX2 →