SCHEMBL1644534

SCHEMBL1644534

Cc1cc(C)cc(Nc2ccc(C3(c4ccccc4)c4ccccc4-c4ccccc43)cc2)c1

nearest known ligand 0.49

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 4/20 0.49
KMT2A Q03164 4/20 0.49
MAPT P10636 4/20 0.49
LMNA P02545 2/20 0.49
KDM4E B2RXH2 1/20 0.49
OPRK1 P41145 1/20 0.49
SMN1; SMN2 Q16637 1/20 0.49
ESR1 P03372 1/20 0.45
ESR2 Q92731 1/20 0.45
POLB P06746 1/20 0.45
NPSR1 Q6W5P4 2/20 0.42
HPGD P15428 1/20 0.42
TP53 P04637 2/20 0.41
PDK2 Q15119 2/20 0.40
NPC1 O15118 1/20 0.40
RAB9A P51151 1/20 0.40
NAT1 P18440 2/20 0.39
KIF11 P52732 1/20 0.36
L3MBTL1 Q9Y468 3/20 0.35
ALDH1A1 P00352 2/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL18735571 0.90 NPSR1 (0.45) MEN1KMT2AMAPTLMNAKDM4E
SCHEMBL25705878 0.89 HPGD (0.55) MEN1KMT2AMAPTLMNAKDM4E
SCHEMBL1645680 0.88 NPSR1 (0.60) MEN1KMT2AMAPTLMNAKDM4E
SCHEMBL19660875 0.87 HPGD (0.49) MEN1KMT2AMAPTLMNAKDM4E
SCHEMBL283063 0.85 MAPT (0.55) MEN1KMT2AMAPTLMNAKDM4E
SCHEMBL30564983 0.85 MAPT (0.55) MEN1KMT2AMAPTLMNAKDM4E
SCHEMBL25701164 0.84 MAPT (0.51) MEN1KMT2AMAPTLMNAKDM4E
SCHEMBL15989738 0.84 PDK2 (0.49) MEN1KMT2AMAPTLMNAKDM4E
SCHEMBL15866664 0.84 MAPT (0.57) MEN1KMT2AMAPTLMNAKDM4E
SCHEMBL29638154 0.83 PDK2 (0.50) MEN1KMT2AMAPTLMNAKDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20170104157-A1 FLUORENE DERIVATIVE, LIGHT-EMITTING ELEMENT, LIGHT-EMITTING DEVICE, ELECTRONIC DEVICE, AND LIGHTING DEVICE SEMICONDUCTOR ENERGY LABORATORY CO., LTD. (JP) 2017-04-13 US disclosed
US-20170104157-A1 FLUORENE DERIVATIVE, LIGHT-EMITTING ELEMENT, LIGHT-EMITTING DEVICE, ELECTRONIC DEVICE, AND LIGHTING DEVICE SEMICONDUCTOR ENERGY LABORATORY CO., LTD. (JP) 2017-04-13 US disclosed
US-9553273-B2 Fluorene derivative, light-emitting element, light-emitting device, electronic device, and lighting device SEMICONDUCTOR ENERGY LABORATORY CO., LTD. (JP) 2017-01-24 US disclosed
US-9553273-B2 Fluorene derivative, light-emitting element, light-emitting device, electronic device, and lighting device SEMICONDUCTOR ENERGY LABORATORY CO., LTD. (JP) 2017-01-24 US disclosed
US-20140131697-A1 FLUORENE DERIVATIVE, LIGHT-EMITTING ELEMENT, LIGHT-EMITTING DEVICE, ELECTRONIC DEVICE, AND LIGHTING DEVICE SEMICONDUCTOR ENERGY LABORATORY CO., LTD. (JP) 2014-05-15 US disclosed
US-20140131697-A1 FLUORENE DERIVATIVE, LIGHT-EMITTING ELEMENT, LIGHT-EMITTING DEVICE, ELECTRONIC DEVICE, AND LIGHTING DEVICE SEMICONDUCTOR ENERGY LABORATORY CO., LTD. (JP) 2014-05-15 US disclosed
US-8642190-B2 Fluorene derivative, light-emitting element, light-emitting device, electronic device, and lighting device SEMICONDUCTOR ENERGY LABORATORY CO., LTD. (JP) 2014-02-04 US disclosed
US-8642190-B2 Fluorene derivative, light-emitting element, light-emitting device, electronic device, and lighting device SEMICONDUCTOR ENERGY LABORATORY CO., LTD. (JP) 2014-02-04 US disclosed
EP-2314565-B1 Fluorene Derivative, Light-Emitting Element, Light-Emitting Device, Electronic Device, and Lighting Device SEMICONDUCTOR ENERGY LAB (JP) 2013-07-24 EP disclosed
EP-2314565-B1 Fluorene Derivative, Light-Emitting Element, Light-Emitting Device, Electronic Device, and Lighting Device SEMICONDUCTOR ENERGY LAB (JP) 2013-07-24 EP disclosed
US-20110095678-A1 FLUORENE DERIVATIVE, LIGHT-EMITTING ELEMENT, LIGHT-EMITTING DEVICE, ELECTRONIC DEVICE, AND LIGHTING DEVICE SEMICONDUCTOR ENERGY LABORATORY CO., LTD. (JP) 2011-04-28 US disclosed
US-20110095678-A1 FLUORENE DERIVATIVE, LIGHT-EMITTING ELEMENT, LIGHT-EMITTING DEVICE, ELECTRONIC DEVICE, AND LIGHTING DEVICE SEMICONDUCTOR ENERGY LABORATORY CO., LTD. (JP) 2011-04-28 US disclosed
EP-2314565-A1 Fluorene Derivative, Light-Emitting Element, Light-Emitting Device, Electronic Device, and Lighting Device SEMICONDUCTOR ENERGY LABORATORY CO., LTD. (JP) 2011-04-27 EP disclosed
EP-2314565-A1 Fluorene Derivative, Light-Emitting Element, Light-Emitting Device, Electronic Device, and Lighting Device SEMICONDUCTOR ENERGY LABORATORY CO., LTD. (JP) 2011-04-27 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20170104157-A1 FLUORENE DERIVATIVE, LIGHT-EMITTING ELEMENT, LIGHT-EMITTING DEVICE, ELECTRONIC DEVICE, AND LIGHTING DEVICE NR2E3, AFF1, LEF1 MEN1 953/4885KMT2A 869/4885MAPT 3410/4885
US-20110095678-A1 FLUORENE DERIVATIVE, LIGHT-EMITTING ELEMENT, LIGHT-EMITTING DEVICE, ELECTRONIC DEVICE, AND LIGHTING DEVICE NR2E3, AFF1, LEF1 MEN1 953/4885KMT2A 869/4885MAPT 3410/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.