SCHEMBL16445371

SCHEMBL16445371

CCCCOC1(c2ccccc2F)CN(C(=O)[C@@H](Cc2ccc(OC)cc2)NC(=O)O)C1

nearest known ligand 0.62

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
MC1R Q01726 9/20 0.62
MC4R P32245 9/20 0.62
KMT2A Q03164 2/20 0.42
ALB P02768 1/20 0.42
IL2 P60568 1/20 0.42
GAA P10253 1/20 0.41
MC5R P33032 1/20 0.39
MC3R P41968 1/20 0.39
MMP3 P08254 1/20 0.38
ITGB1 P05556 1/20 0.37
ITGA4 P13612 1/20 0.37
FPR2 P25090 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16188227 0.91 MC1R (0.72) MC1RMC4RKMT2AMC5RMC3R
SCHEMBL16444996 0.90 MC1R (0.70) MC1RMC4RKMT2AMC5RMC3R
SCHEMBL2148982 0.89 MC1R (0.57) MC1RMC4RKMT2A
Trifluoroacetic Acid SCHEMBL1310165 0.84 MC1R (0.49) MC1RMC4R
SCHEMBL16445574 0.83 MC1R (0.61) MC1RMC4RKMT2AITGB1ITGA4
SCHEMBL20450446 0.83 MC1R (0.69) MC1RMC4RKMT2AALBIL2
SCHEMBL1310104 0.83 MC1R (0.69) MC1RMC4RKMT2AALBIL2
SCHEMBL14360222 0.82 MC1R (0.61) MC1RMC4RKMT2A
SCHEMBL1310666 0.82 MC1R (0.47) MC1RMC4RKMT2AGAAMMP3
SCHEMBL16445351 0.81 MC1R (0.73) MC1RMC4RKMT2AGAA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2342194-B1 OXOAZETIDINE DERIVATIVES, PROCESS FOR THE PREPARATION THEREOF AND USE THEREOF IN HUMAN MEDICINE AND IN COSMETICS GALDERMA RES & DEV (FR) 2018-08-08 EP disclosed
US-9630949-B2 Oxoazetidine derivatives, process for the preparation thereof and use thereof in human medicine and in cosmetics GALDERMA RESEARCH & DEVELOPMENT (FR) 2017-04-25 US disclosed
US-20150045559-A1 OXOAZETIDINE DERIVATIVES, PROCESS FOR THE PREPARATION THEREOF AND USE THEREOF IN HUMAN MEDICINE AND IN COSMETICS GALDERMA RESEARCH & DEVELOPMENT (FR) 2015-02-12 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20150045559-A1 OXOAZETIDINE DERIVATIVES, PROCESS FOR THE PREPARATION THEREOF AND USE THEREOF IN HUMAN MEDICINE AND IN COSMETICS CYP51A1, TYR, CYP2C19 MC1R 195/4885MC4R 873/4885KMT2A 1928/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.