Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCNN1A | P37088 | 7/20 | 0.49 |
| ▸ | CTSA | P10619 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL16443350 | 0.80 | SCNN1A (0.49) | SCNN1A | |
| SCHEMBL16453222 | 0.79 | SCNN1A (0.50) | SCNN1A | |
| Hydrochloric Acid SCHEMBL16446844 | 0.76 | UTS2R (0.42) | SCNN1ACTSA | |
| Hydrochloric Acid SCHEMBL20677585 | 0.76 | SCNN1A (0.52) | SCNN1A | |
| Hydrochloric Acid SCHEMBL16443569 | 0.76 | SCNN1A (0.53) | SCNN1A | |
| Hydrochloric Acid SCHEMBL20677597 | 0.75 | SCNN1A (0.53) | SCNN1A | |
| Hydrochloric Acid SCHEMBL20677507 | 0.75 | SCNN1A (0.53) | SCNN1A | |
| Hydrochloric Acid SCHEMBL16443823 | 0.75 | SCNN1A (0.53) | SCNN1A | |
| SCHEMBL16453255 | 0.75 | SCNN1A (0.53) | SCNN1A | |
| SCHEMBL16453221 | 0.75 | SCNN1A (0.53) | SCNN1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3030555-A1 | NOVEL PYRAZINE AMIDE COMPOUNDS | Boehringer Ingelheim International GmbH (DE) | 2016-06-15 | — | — | EP | disclosed |
| WO-2015018754-A1 | NOVEL PYRAZINE AMIDE COMPOUNDS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2015-02-12 | — | — | WO | disclosed |