Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 10/20 | 0.52 |
| ▸ | PTK2 | Q05397 | 2/20 | 0.40 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.38 |
| ▸ | CDK8 | P49336 | 1/20 | 0.38 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | GGPS1 | O95749 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | HAVCR2 | Q8TDQ0 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17784208 | 0.93 | PDE4B (0.54) | PDE4BPTK2RAB9ATSHRSMN1; SMN2 | |
| SCHEMBL17784207 | 0.91 | PDE4B (0.55) | PDE4BPTK2TSHRGGPS1MEN1 | |
| SCHEMBL16448257 | 0.89 | PDE4B (0.53) | PDE4BTSHRGGPS1MEN1MAPT | |
| SCHEMBL17784235 | 0.88 | PDE4B (0.56) | PDE4BTSHRGGPS1MEN1MAPT | |
| SCHEMBL19118056 | 0.87 | PDE4B (0.60) | PDE4BTSHRGGPS1MAPT | |
| SCHEMBL16447934 | 0.86 | PDE4B (0.54) | PDE4BSMN1; SMN2 | |
| SCHEMBL17784209 | 0.85 | PDE4B (0.58) | PDE4BTSHRSMN1; SMN2MEN1MAPT | |
| SCHEMBL17784202 | 0.84 | PDE4B (0.53) | PDE4BMEN1KMT2A | |
| SCHEMBL17784226 | 0.84 | PDE4B (0.52) | PDE4BSMN1; SMN2MAPT | |
| SCHEMBL17784217 | 0.82 | PDE4B (0.60) | PDE4BSMN1; SMN2GGPS1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3030565-B1 | NOVEL SUBSTITUTED CONDENSED PYRIMIDINE COMPOUNDS | GRUENENTHAL GMBH (DE) | 2017-07-19 | — | — | EP | disclosed |
| EP-3030565-A1 | NOVEL SUBSTITUTED CONDENSED PYRIMIDINE COMPOUNDS | Grünenthal GmbH (DE) | 2016-06-15 | — | — | EP | disclosed |
| WO-2015018534-A1 | NOVEL SUBSTITUTED CONDENSED PYRIMIDINE COMPOUNDS | Grünenthal GmbH (DE) | 2015-02-12 | — | — | WO | disclosed |