Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 10/20 | 0.60 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.36 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.36 |
| ▸ | GGPS1 | O95749 | 2/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.35 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.34 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17784217 | 0.92 | PDE4B (0.60) | PDE4BGGPS1GRIN2B | |
| SCHEMBL17784235 | 0.91 | PDE4B (0.56) | PDE4BGGPS1TSHRMAPT | |
| SCHEMBL16448346 | 0.90 | PDE4B (0.58) | PDE4BGRIN2B | |
| SCHEMBL19119081 | 0.90 | PDE4B (0.54) | PDE4BTSHRGRIN2BMAPTRXFP1 | |
| SCHEMBL17784207 | 0.90 | PDE4B (0.55) | PDE4BGGPS1TSHRMAPT | |
| SCHEMBL17784225 | 0.90 | PDE4B (0.64) | PDE4BROCK2ROCK1GGPS1TSHR | |
| SCHEMBL17784208 | 0.89 | PDE4B (0.54) | PDE4BGGPS1TSHRMAPT | |
| SCHEMBL19118428 | 0.88 | PDE4B (0.55) | PDE4BTSHRMAPT | |
| SCHEMBL17784210 | 0.88 | PDE4B (0.50) | PDE4BGRM1GRIN2B | |
| SCHEMBL16448257 | 0.88 | PDE4B (0.53) | PDE4BROCK2ROCK1GGPS1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3030565-B1 | NOVEL SUBSTITUTED CONDENSED PYRIMIDINE COMPOUNDS | GRUENENTHAL GMBH (DE) | 2017-07-19 | — | — | EP | disclosed |