Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.43 |
| ▸ | GAA | P10253 | 4/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | LMNA | P02545 | 4/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | GALR2 | O43603 | 1/20 | 0.39 |
| ▸ | MITF | O75030 | 1/20 | 0.39 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | XBP1 | P17861 | 1/20 | 0.39 |
| ▸ | CCR6 | P51684 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3449671 | 0.85 | MAPT (0.47) | MAPTGAAKDM4EALDH1A1LMNA | |
| SCHEMBL21685540 | 0.85 | MAPT (0.41) | MAPTGAAKDM4EALDH1A1LMNA | |
| SCHEMBL21685703 | 0.83 | MAPT (0.39) | MAPTGAAKDM4EALDH1A1LMNA | |
| SCHEMBL16449128 | 0.82 | NQO2 (0.46) | MAPTGAAKDM4EALDH1A1LMNA | |
| SCHEMBL3300905 | 0.81 | ALDH1A1 (0.48) | MAPTGAAKDM4EALDH1A1LMNA | |
| SCHEMBL29722774 | 0.81 | ALDH1A1 (0.48) | MAPTGAAKDM4EALDH1A1LMNA | |
| SCHEMBL28551635 | 0.79 | MAPT (0.45) | MAPTGAAKDM4EALDH1A1LMNA | |
| SCHEMBL9064586 | 0.78 | MAPT (0.44) | MAPTGAAKDM4EALDH1A1LMNA | |
| SCHEMBL1285715 | 0.77 | AR (0.44) | MAPTGAAKDM4EALDH1A1LMNA | |
| SCHEMBL2928075 | 0.76 | ALDH1A1 (0.44) | MAPTGAAKDM4EALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8952014-B2 | Pyrimidine derivatives which are CGRP—antagonists | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2015-02-10 | — | — | US | disclosed |