SCHEMBL16449874

SCHEMBL16449874

COc1cc(N=Nc2cccc([N+](=O)[O-])c2)c(NC(C)=O)cc1N=Nc1ccc2cc(S(=O)(=O)O)cc(N)c2c1O

nearest known ligand 0.43

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
▸ ENPP2 Q13822 9/20 0.43
▸ PHLPP2 Q6ZVD8 2/20 0.38
▸ CA1 P00915 1/20 0.37
▸ CA2 P00918 1/20 0.37
▸ CA7 P43166 1/20 0.37
▸ PTPN11 Q06124 1/20 0.37
▸ APEX1 P27695 1/20 0.37
▸ MEN1 O00255 2/20 0.36
▸ KMT2A Q03164 2/20 0.36
▸ SUMO2 P61956 2/20 0.35
▸ SUMO1 P63165 2/20 0.35
▸ SENP7 Q9BQF6 2/20 0.35
▸ SENP2 Q9HC62 2/20 0.35
▸ HTT P42858 1/20 0.35
▸ BRD4 O60885 1/20 0.35
▸ PRMT1 Q99873 1/20 0.34
▸ SENP3 Q9H4L4 1/20 0.34
▸ SENP1 Q9P0U3 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16451679 0.90 ENPP2 (0.56) ENPP2PHLPP2CA2MEN1KMT2A
SCHEMBL16449884 0.87 ENPP2 (0.45) ENPP2PHLPP2APEX1MEN1KMT2A
SCHEMBL16452394 0.78 ENPP2 (0.58) ENPP2PHLPP2CA2MEN1KMT2A
SCHEMBL9180969 0.78 ENPP2 (0.49) ENPP2PHLPP2PTPN11MEN1KMT2A
SCHEMBL16449867 0.77 ENPP2 (0.49) ENPP2PHLPP2APEX1MEN1KMT2A
SCHEMBL16449875 0.76 CYP3A4 (0.57) ENPP2PHLPP2CA2APEX1MEN1
SCHEMBL29702427 0.75 ENPP2 (0.55) ENPP2PHLPP2PTPN11APEX1MEN1
SCHEMBL18218143 0.75 ENPP2 (0.46) ENPP2APEX1MEN1KMT2AHTT
SCHEMBL9179502 0.74 ENPP2 (0.54) ENPP2PHLPP2CA2PTPN11SUMO2
SCHEMBL10448648 0.74 ENPP2 (0.54) ENPP2PHLPP2CA2PTPN11SUMO2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20150041734-A1 POLARIZING FILM, IMAGE DISPLAY, AND METHOD FOR PRODUCING POLARIZING FILM NITTO DENKO CORPORATION (JP) 2015-02-12 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20150041734-A1 POLARIZING FILM, IMAGE DISPLAY, AND METHOD FOR PRODUCING POLARIZING FILM PYM1, H1-0, CHRM1 ENPP2 3218/4885PHLPP2 2633/4885CA1 544/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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