Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 18/20 | 0.48 |
| ▸ | SLC6A4 | P31645 | 18/20 | 0.48 |
| ▸ | SLC6A3 | Q01959 | 18/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 17/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18597526 | 1.00 | SLC6A2 (0.48) | SLC6A2SLC6A4SLC6A3CYP2D6CYP2C19 | |
| SCHEMBL25962718 | 0.89 | SLC6A2 (0.40) | SLC6A2SLC6A4SLC6A3CYP2D6CYP2C19 | |
| SCHEMBL1292699 | 0.88 | CYP2D6 (0.41) | SLC6A2SLC6A4SLC6A3CYP2D6CYP2C19 | |
| Hydrochloric Acid SCHEMBL28328339 | 0.87 | SLC6A2 (0.40) | SLC6A2SLC6A4SLC6A3CYP2D6CYP2C19 | |
| SCHEMBL16450958 | 0.85 | SLC6A2 (0.45) | SLC6A2SLC6A4SLC6A3CYP2D6 | |
| SCHEMBL29951019 | 0.84 | SLC6A2 (0.39) | SLC6A2SLC6A4SLC6A3CYP2D6CYP2C19 | |
| SCHEMBL15367695 | 0.83 | CYP2D6 (0.44) | SLC6A2SLC6A4SLC6A3CYP2D6 | |
| SCHEMBL414945 | 0.81 | SLC6A2 (0.58) | SLC6A2SLC6A4SLC6A3CYP2D6 | |
| SCHEMBL15367602 | 0.80 | CYP2D6 (0.42) | SLC6A2SLC6A4SLC6A3CYP2D6 | |
| SCHEMBL15353448 | 0.79 | OPRM1 (0.43) | SLC6A2SLC6A4SLC6A3CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9527810-B2 | (3,4-dichloro-phenyl)-((S)-3-propyl-pyrrolidin-3-yl)-methanone hydrochloride and manufacturing processes | HOFFMANN-LA ROCHE INC. (US) | 2016-12-27 | — | — | US | disclosed |
| US-9527810-B2 | (3,4-dichloro-phenyl)-((S)-3-propyl-pyrrolidin-3-yl)-methanone hydrochloride and manufacturing processes | HOFFMANN-LA ROCHE INC. (US) | 2016-12-27 | — | — | US | disclosed |
| US-20150045408-A1 | (3,4-DICHLORO-PHENYL)-((S)-3-PROPYL-PYRROLIDIN-3-YL)-METHANONE HYDROCHLORIDE AND MANUFACTURING PROCESSES | HOFFMANN-LA ROCHE INC. (US) | 2015-02-12 | — | — | US | disclosed |
| US-20150045408-A1 | (3,4-DICHLORO-PHENYL)-((S)-3-PROPYL-PYRROLIDIN-3-YL)-METHANONE HYDROCHLORIDE AND MANUFACTURING PROCESSES | HOFFMANN-LA ROCHE INC. (US) | 2015-02-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150045408-A1 | (3,4-DICHLORO-PHENYL)-((S)-3-PROPYL-PYRROLIDIN-3-YL)-METHANONE HYDROCHLORIDE AND MANUFACTURING PROCESSES | CYP2C19, CYP2D6, CYP4B1 | SLC6A2 2974/4885SLC6A4 1316/4885SLC6A3 640/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.