Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 13/20 | 0.84 |
| ▸ | APP | P05067 | 3/20 | 0.67 |
| ▸ | MAPT | P10636 | 2/20 | 0.67 |
| ▸ | CAPN1 | P07384 | 1/20 | 0.59 |
| ▸ | NFE2L2 | Q16236 | 2/20 | 0.55 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.50 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.50 |
| ▸ | MAOA | P21397 | 1/20 | 0.50 |
| ▸ | MAOB | P27338 | 1/20 | 0.50 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.50 |
| ▸ | DPP4 | P27487 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1645403 | 1.00 | BACE1 (0.84) | BACE1APPMAPTCAPN1NFE2L2 | |
| SCHEMBL3218840 | 0.92 | BACE1 (1.00) | BACE1APPMAPTCAPN1NFE2L2 | |
| SCHEMBL3218814 | 0.92 | BACE1 (1.00) | BACE1APPMAPTCAPN1NFE2L2 | |
| SCHEMBL1647560 | 0.91 | APP (0.82) | BACE1APPMAPTCAPN1NFE2L2 | |
| SCHEMBL1647558 | 0.91 | APP (0.82) | BACE1APPMAPTCAPN1NFE2L2 | |
| SCHEMBL1647145 | 0.87 | BACE1 (0.85) | BACE1APPMAPTAKR1B1MAOB | |
| SCHEMBL1647148 | 0.87 | BACE1 (0.85) | BACE1APPMAPTAKR1B1MAOB | |
| SCHEMBL3200576 | 0.85 | BACE1 (0.86) | BACE1APPMAPTCAPN1ABCB1 | |
| SCHEMBL3200593 | 0.85 | BACE1 (0.86) | BACE1APPMAPTCAPN1ABCB1 | |
| SCHEMBL1646655 | 0.83 | BACE1 (0.74) | BACE1APPMAPTAKR1B1MAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8552220-B2 | Therapeutic agent for Alzheimer's disease | TOKYO INSTITUTE OF TECHNOLOGY (JP) | 2013-10-08 | — | — | US | disclosed |
| EP-2305629-A1 | THERAPEUTIC AGENT FOR ALZHEIMER'S DISEASE | Tokyo Institute of Technology (JP) | 2011-04-06 | — | — | EP | disclosed |