Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 14/20 | 0.85 |
| ▸ | APP | P05067 | 2/20 | 0.55 |
| ▸ | AKR1B10 | O60218 | 1/20 | 0.52 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.52 |
| ▸ | MAOB | P27338 | 1/20 | 0.52 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.52 |
| ▸ | GLO1 | Q04760 | 1/20 | 0.52 |
| ▸ | CAMK2A | Q9UQM7 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 3/20 | 0.48 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1647145 | 1.00 | BACE1 (0.85) | BACE1APPAKR1B10AKR1B1MAOB | |
| SCHEMBL1648591 | 0.92 | BACE1 (1.00) | BACE1AKR1B10AKR1B1MAOBPTGS2 | |
| SCHEMBL1646656 | 0.92 | BACE1 (0.74) | BACE1APPAKR1B10AKR1B1MAOB | |
| SCHEMBL1648589 | 0.92 | BACE1 (1.00) | BACE1AKR1B10AKR1B1MAOBPTGS2 | |
| SCHEMBL1646655 | 0.92 | BACE1 (0.74) | BACE1APPAKR1B10AKR1B1MAOB | |
| SCHEMBL1645401 | 0.87 | BACE1 (0.84) | BACE1APPAKR1B1MAOBMAPT | |
| SCHEMBL1645403 | 0.87 | BACE1 (0.84) | BACE1APPAKR1B1MAOBMAPT | |
| SCHEMBL1647560 | 0.86 | APP (0.82) | BACE1APPAKR1B10AKR1B1MAPT | |
| SCHEMBL1647106 | 0.86 | BACE1 (0.74) | BACE1APPMAPTALOX5MEN1 | |
| SCHEMBL1647558 | 0.86 | APP (0.82) | BACE1APPAKR1B10AKR1B1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8552220-B2 | Therapeutic agent for Alzheimer's disease | TOKYO INSTITUTE OF TECHNOLOGY (JP) | 2013-10-08 | — | — | US | disclosed |
| EP-2305629-A1 | THERAPEUTIC AGENT FOR ALZHEIMER'S DISEASE | Tokyo Institute of Technology (JP) | 2011-04-06 | — | — | EP | disclosed |