Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.65 |
| ▸ | TP53 | P04637 | 2/20 | 0.65 |
| ▸ | MAPT | P10636 | 2/20 | 0.65 |
| ▸ | RAB9A | P51151 | 2/20 | 0.65 |
| ▸ | MEN1 | O00255 | 1/20 | 0.65 |
| ▸ | PKM | P14618 | 1/20 | 0.65 |
| ▸ | TSHR | P16473 | 1/20 | 0.65 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.65 |
| ▸ | KMO | O15229 | 2/20 | 0.50 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.47 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | CCR1 | P32246 | 2/20 | 0.46 |
| ▸ | CCR5 | P51681 | 2/20 | 0.46 |
| ▸ | CCR8 | P51685 | 2/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18015401 | 0.86 | NPC1 (0.54) | NPC1TP53MAPTRAB9AMEN1 | |
| SCHEMBL15075728 | 0.83 | NPC1 (0.62) | NPC1TP53MAPTRAB9AMEN1 | |
| SCHEMBL7662434 | 0.83 | KDM4E (0.56) | NPC1TP53MAPTRAB9AMEN1 | |
| SCHEMBL21022955 | 0.80 | NPC1 (0.49) | NPC1TP53MAPTRAB9AMEN1 | |
| SCHEMBL23253142 | 0.79 | KDM4E (0.50) | NPC1TP53MAPTRAB9AMEN1 | |
| SCHEMBL30610285 | 0.79 | NPC1 (0.47) | NPC1TP53MAPTRAB9AMEN1 | |
| SCHEMBL23525622 | 0.79 | NPC1 (0.47) | NPC1TP53MAPTRAB9AMEN1 | |
| SCHEMBL29901515 | 0.79 | RAB9A (0.50) | NPC1TP53MAPTRAB9AMEN1 | |
| SCHEMBL23525612 | 0.79 | RET (0.50) | NPC1TP53MAPTRAB9AMEN1 | |
| SCHEMBL30610290 | 0.79 | RET (0.50) | NPC1TP53MAPTRAB9AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1861387-B1 | BENZIMIDAZOLE DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS THEREOF | DAE WOONG PHARMA (KR) | 2014-04-16 | — | — | EP | disclosed |
| CN-103180308-A | Novel process for preparing benzimidazole derivatives | DAE WOONG PHARMA | 2013-06-26 | — | — | CN | disclosed |