Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | WNT1 | P04628 | 1/20 | 0.31 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.31 |
| ▸ | EGFR | P00533 | 1/20 | 0.31 |
| ▸ | LCK | P06239 | 1/20 | 0.31 |
| ▸ | JAK3 | P52333 | 1/20 | 0.31 |
| ▸ | BTK | Q06187 | 1/20 | 0.31 |
| ▸ | IL1B | P01584 | 1/20 | 0.30 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.30 |
| ▸ | BMPR1A | P36894 | 1/20 | 0.30 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.30 |
| ▸ | ACVRL1 | P37023 | 1/20 | 0.30 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.30 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1120117 | 0.90 | MAPK14 (0.32) | EGFRLCKJAK3BTKIL1B | |
| SCHEMBL1962713 | 0.90 | BMPR1B (0.34) | EGFRLCKJAK3BTKIL1B | |
| SCHEMBL1962175 | 0.90 | GSK3B (0.35) | EGFRLCKJAK3BTKIL1B | |
| SCHEMBL1960445 | 0.82 | ACKR3 (0.36) | EGFRLCKJAK3BTKBMPR1B | |
| SCHEMBL8003442 | 0.81 | GSK3B (0.37) | EGFRLCKJAK3BTK | |
| SCHEMBL1119579 | 0.80 | BMPR1B (0.32) | EGFRLCKJAK3BTKBMPR1B | |
| SCHEMBL12579257 | 0.80 | BMPR1B (0.31) | IL1BBMPR1BBMPR1ATGFBR1ACVRL1 | |
| SCHEMBL1962515 | 0.77 | DPP4 (0.34) | — | |
| SCHEMBL1120223 | 0.77 | DPP4 (0.34) | — | |
| SCHEMBL1119497 | 0.74 | MAPK14 (0.34) | BMPR1BBMPR1ATGFBR1ACVRL1ACVR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2280976-B1 | SUBSTITUTED IMIDAZO- AND TRIAZOLOPYRIMIDINES, IMIDAZO- AND PYRAZOLOPYRAZINES AND IMIDAZOTRIAZINES AS GSK3BETA-INHIBITORS | BAYER IP GMBH (DE) | 2014-01-01 | — | — | EP | disclosed |