Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NUDT1 | P36639 | 2/20 | 0.42 |
| ▸ | AXL | P30530 | 1/20 | 0.42 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.41 |
| ▸ | IDO1 | P14902 | 1/20 | 0.41 |
| ▸ | CDK2 | P24941 | 1/20 | 0.41 |
| ▸ | DAO | P14920 | 1/20 | 0.39 |
| ▸ | PIM1 | P11309 | 1/20 | 0.38 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.38 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.38 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.37 |
| ▸ | IKBKE | Q14164 | 1/20 | 0.36 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.36 |
| ▸ | NOS1 | P29475 | 2/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.36 |
| ▸ | PARP1 | P09874 | 1/20 | 0.36 |
| ▸ | PRKCI | P41743 | 1/20 | 0.36 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7679 | 0.90 | — | — | |
| SCHEMBL29365139 | 0.90 | — | — | |
| SCHEMBL23159915 | 0.88 | NUDT1 (0.48) | NUDT1AXLHSP90AA1IDO1CDK2 | |
| Hydrochloric Acid SCHEMBL16296100 | 0.88 | NUDT1 (0.48) | NUDT1AXLHSP90AA1IDO1CDK2 | |
| Urea SCHEMBL28419880 | 0.79 | FLT3 (0.49) | NUDT1AXLHSP90AA1IDO1CDK2 | |
| Dipyridyl SCHEMBL28565857 | 0.79 | KDM4E (0.52) | HSP90AA1IDO1CDK2PIM1TDP1 | |
| SCHEMBL5025757 | 0.77 | CDK2 (0.50) | NUDT1AXLHSP90AA1IDO1CDK2 | |
| SCHEMBL11903658 | 0.77 | CDK2 (0.50) | NUDT1AXLHSP90AA1IDO1CDK2 | |
| Fumaric Acid SCHEMBL10591225 | 0.75 | KDM4E (0.49) | NUDT1AXLDAOPIM1PIM3 | |
| Maleic Acid SCHEMBL10591220 | 0.75 | KDM4E (0.49) | NUDT1AXLDAOPIM1PIM3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2682394-A1 | 1H-pyrazolo[3,4-b]pyridin-triazine derivatives and their use for the treatment or the prevention of cardiovascular diseases | Bayer Intellectual Property GmbH (DE) | 2014-01-08 | — | — | EP | disclosed |