Known targets — ChEMBL curated mechanism
ACHECHKACHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGHRH2OPRM1
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.58 |
| ▸ | LMNA | P02545 | 5/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 8/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.50 |
| ▸ | HTT | P42858 | 3/20 | 0.50 |
| ▸ | MITF | O75030 | 1/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | RECQL | P46063 | 1/20 | 0.49 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.49 |
| ▸ | ATM | Q13315 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 3/20 | 0.47 |
| ▸ | ALPG | P10696 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | GLA | P06280 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2230581 | 0.98 | KDM4E (0.59) | KDM4ELMNASMN1; SMN2KMT2AALDH1A1 | |
| Bromide SCHEMBL3883521 | 0.84 | KDM4E (0.78) | KDM4ELMNASMN1; SMN2KMT2AALDH1A1 | |
| Bromide SCHEMBL3888558 | 0.79 | KMT2A (0.67) | KDM4ELMNASMN1; SMN2KMT2AALDH1A1 | |
| Bromide SCHEMBL3884195 | 0.79 | KMT2A (0.70) | KDM4ELMNASMN1; SMN2KMT2AALDH1A1 | |
| SCHEMBL4898501 | 0.78 | KMT2A (0.64) | KDM4ELMNASMN1; SMN2KMT2AALDH1A1 | |
| Bromide SCHEMBL1645919 | 0.78 | KMT2A (0.73) | KDM4ELMNASMN1; SMN2KMT2AALDH1A1 | |
| SCHEMBL4896174 | 0.77 | KMT2A (0.68) | KDM4ESMN1; SMN2KMT2AALDH1A1POLB | |
| SCHEMBL13394254 | 0.76 | KMT2A (0.70) | KDM4ELMNASMN1; SMN2KMT2AALDH1A1 | |
| Bromide SCHEMBL3883473 | 0.72 | THRB (0.58) | KDM4ELMNASMN1; SMN2KMT2AALDH1A1 | |
| Bromide SCHEMBL6225621 | 0.72 | KMT2A (0.68) | KDM4ELMNAKMT2AALDH1A1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2303329-A1 | ANTIFUNGAL COMBINATION THERAPY | F2G Limited (GB) | 2011-04-06 | — | — | EP | disclosed |
| WO-2009144473-A1 | ANTIFUNGAL COMBINATION THERAPY | F2G LIMITED (GB) | 2009-12-03 | — | — | WO | disclosed |
| EP-2097413-A1 | 2-[(2-SUBSTITUTED)-IND0LIZIN-3-YL]-2-OXO-ACETAMIDE DERIVATIVES AS ANTIFUNGAL AGENTS | F2G Limited (GB) | 2009-09-09 | — | — | EP | disclosed |
| WO-2008062182-A1 | 2- [ (2-SUBSTITUTED) -IND0LIZIN-3-YL] -2-OXO-ACETAMIDE DERIVATIVES AS ANTIFUNGAL AGENTS | F2G LTD (GB) | 2008-05-29 | — | — | WO | disclosed |