Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNA5 | P22460 | 8/20 | 0.55 |
| ▸ | KCNJ5 | P48544 | 6/20 | 0.40 |
| ▸ | KCNJ3 | P48549 | 6/20 | 0.40 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16457840 | 1.00 | KCNA5 (0.55) | KCNA5KCNJ5KCNJ3P2RX7 | |
| SCHEMBL12080599 | 0.87 | KCNA5 (0.65) | KCNA5KCNJ5KCNJ3P2RX7 | |
| SCHEMBL12081298 | 0.87 | KCNA5 (0.65) | KCNA5KCNJ5KCNJ3P2RX7 | |
| SCHEMBL16457741 | 0.85 | KCNA5 (0.55) | KCNA5KCNJ5KCNJ3P2RX7 | |
| SCHEMBL16458137 | 0.85 | KCNA5 (0.55) | KCNA5KCNJ5KCNJ3P2RX7 | |
| SCHEMBL1236706 | 0.81 | KCNA5 (0.77) | KCNA5KCNJ5KCNJ3 | |
| SCHEMBL12081267 | 0.80 | KCNA5 (0.75) | KCNA5KCNJ5KCNJ3 | |
| SCHEMBL12081577 | 0.80 | KCNA5 (0.75) | KCNA5KCNJ5KCNJ3 | |
| SCHEMBL12081360 | 0.80 | KCNA5 (0.58) | KCNA5KCNJ5KCNJ3P2RX7 | |
| SCHEMBL12081353 | 0.80 | KCNA5 (0.58) | KCNA5KCNJ5KCNJ3P2RX7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2467364-B9 | NITROGEN-CONTAINING COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS THEREOF FOR THE TREATMENT OF ATRIAL FIBRILLATION | OTSUKA PHARMA CO LTD (JP) | 2015-02-18 | — | — | EP | disclosed |
| EP-2467364-B1 | NITROGEN-CONTAINING COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS THEREOF FOR THE TREATMENT OF ATRIAL FIBRILLATION | OTSUKA PHARMA CO LTD (JP) | 2014-04-16 | — | — | EP | disclosed |