Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FOLH1 | Q04609 | 9/20 | 0.58 |
| ▸ | CAPN1 | P07384 | 2/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | PSEN1 | P49768 | 2/20 | 0.49 |
| ▸ | PSEN2 | P49810 | 2/20 | 0.49 |
| ▸ | APH1B | Q8WW43 | 2/20 | 0.49 |
| ▸ | NCSTN | Q92542 | 2/20 | 0.49 |
| ▸ | APH1A | Q96BI3 | 2/20 | 0.49 |
| ▸ | PSENEN | Q9NZ42 | 2/20 | 0.49 |
| ▸ | CASP3 | P42574 | 2/20 | 0.48 |
| ▸ | CASP1 | P29466 | 1/20 | 0.48 |
| ▸ | CASP2 | P42575 | 1/20 | 0.48 |
| ▸ | CASP7 | P55210 | 1/20 | 0.48 |
| ▸ | CASP8 | Q14790 | 1/20 | 0.48 |
| ▸ | PRSS1 | P07477 | 2/20 | 0.47 |
| ▸ | PRSS2 | P07478 | 2/20 | 0.47 |
| ▸ | PRSS3 | P35030 | 2/20 | 0.47 |
| ▸ | TPSAB1 | Q15661 | 2/20 | 0.47 |
| ▸ | F2 | P00734 | 1/20 | 0.47 |
| ▸ | PLG | P00747 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17244680 | 0.97 | FOLH1 (0.61) | FOLH1CAPN1TDP1PSEN1PSEN2 | |
| SCHEMBL16458125 | 0.97 | FOLH1 (0.61) | FOLH1CAPN1TDP1PSEN1PSEN2 | |
| SCHEMBL16478827 | 0.94 | FOLH1 (0.64) | FOLH1CAPN1TDP1PSEN1PSEN2 | |
| SCHEMBL16478788 | 0.89 | FOLH1 (0.56) | FOLH1CAPN1TDP1PSEN1PSEN2 | |
| SCHEMBL16458328 | 0.89 | FOLH1 (0.62) | FOLH1CAPN1TDP1CASP3CASP1 | |
| SCHEMBL16458630 | 0.87 | FOLH1 (0.50) | FOLH1CAPN1PSEN1PSEN2APH1B | |
| SCHEMBL24313157 | 0.86 | F2 (0.60) | FOLH1CAPN1TDP1PRSS1PRSS2 | |
| SCHEMBL17244682 | 0.86 | FOLH1 (0.65) | FOLH1CAPN1TDP1CASP3CASP1 | |
| SCHEMBL22769248 | 0.86 | FOLH1 (0.65) | FOLH1CAPN1TDP1CASP3CASP1 | |
| SCHEMBL17244679 | 0.85 | TDP1 (0.63) | FOLH1CAPN1TDP1PSEN1PSEN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9766235-B2 | Trifunctional crosslinking reagents | ETH ZURICH (CH) | 2017-09-19 | — | — | US | disclosed |
| EP-2670755-B1 | TRIFUNCTIONAL CROSSLINKING REAGENTS | ETH ZUERICH (CH) | 2016-10-12 | — | — | EP | disclosed |
| EP-2942351-B1 | TRIFUNCTIONAL CROSSLINKING REAGENTS | ETH ZUERICH (CH) | 2016-10-12 | — | — | EP | disclosed |
| US-20140011212-A1 | TRIFUNCTIONAL CROSSLINKING REAGENTS | ETH ZURICH (CH) | 2014-01-09 | — | — | US | disclosed |