Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 15/20 | 0.47 |
| ▸ | PDE4A | P27815 | 9/20 | 0.45 |
| ▸ | PDE4C | Q08493 | 4/20 | 0.44 |
| ▸ | PDE4D | Q08499 | 4/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16458681 | 1.00 | PDE4B (0.47) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL873439 | 0.86 | PDE4A (0.45) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL2141419 | 0.85 | PDE4B (0.50) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL682651 | 0.85 | PDE4B (0.50) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL874555 | 0.84 | PDE4B (0.46) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL873257 | 0.84 | PDE4B (0.51) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL682529 | 0.84 | PDE4B (0.50) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL682647 | 0.84 | PDE4B (0.49) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL873628 | 0.84 | PDE4B (0.50) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL2085057 | 0.84 | PDE4B (0.49) | PDE4BPDE4APDE4CPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2562168-B1 | THERAPEUTIC PIPERAZINES AS PDE4 INHIBITORS | DART NEUROSCIENCE CAYMAN LTD (KY) | 2014-04-16 | — | — | EP | disclosed |