Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.30 |
| ▸ | ACHE | P22303 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL163943 | 0.97 | PARP1 (0.46) | PARP1GAAMAPT | |
| Water SCHEMBL15092682 | 0.97 | PARP1 (0.41) | PARP1GAAMAPT | |
| Bromide SCHEMBL166261 | 0.97 | PARP1 (0.41) | PARP1GAAMAPT | |
| Hydrochloric Acid SCHEMBL166212 | 0.94 | PARP1 (0.44) | PARP1GAAMAPT | |
| Methyl Alcohol SCHEMBL15757621 | 0.91 | PARP1 (0.38) | PARP1GAAMAPTTSHRLMNA | |
| Acetone SCHEMBL28779633 | 0.84 | SMN1; SMN2 (0.37) | PARP1GAAMAPTTSHRLMNA | |
| SCHEMBL11072820 | 0.81 | KEAP1 (0.35) | PARP1MAPTTSHRLMNAALOX12 | |
| Maleic Acid SCHEMBL29935550 | 0.79 | HCAR2 (0.43) | MAPTTSHRLMNA | |
| Fumaric Acid SCHEMBL5330585 | 0.79 | HCAR2 (0.43) | MAPTTSHRLMNA | |
| Fumaric Acid SCHEMBL165681 | 0.79 | HCAR2 (0.43) | MAPTTSHRLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 421 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116473978-A | Dosing regimen for treating solid tumors | 伊莱利利公司 | 2023-07-25 | — | — | CN | claimed |
| CN-115845070-A | Combination therapy with NOTCH and PD-1 or PD-L1 inhibitors | 伊莱利利公司 | 2023-03-28 | — | — | CN | claimed |
| CN-112946143-B | Analysis and detection method of 7, 8-dimethoxy-1, 3-dihydro-2H-3-benzazepin-2-ketone | 海南鑫开源医药科技有限公司 | 2023-02-28 | — | — | CN | claimed |
| EP-3728248-A1 | AZAINDOLE DERIVATIVES AS RHO-KINASE INHIBITORS | Chiesi Farmaceutici S.p.A. (IT) | 2020-10-28 | — | — | EP | claimed |
| EP-3324950-A1 | TREATMENT FOR VITILIGO | Glaxo Group Limited (GB) | 2018-05-30 | — | — | EP | claimed |
| WO-2017017571-A1 | TREATMENT FOR VITILIGO | GLAXO GROUP LIMITED (GB) | 2017-02-02 | — | — | WO | claimed |
| EP-2099743-B1 | PROCESSES FOR PREPARING (R)-8-CHLORO-1-METHYL-2,3,4,5-TETRAHYDRO-1H-3-BENZAZEPINE AND INTERMEDIATES THEREOF | ARENA PHARM INC (US) | 2014-08-27 | — | — | EP | claimed |
| CN-101547892-B | Processes for preparing (r)-8-chloro-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine and intermediates thereof | ARENA PHARM INC | 2014-08-20 | — | — | CN | claimed |
| EP-2683709-A1 | PYRIDINYL- AND PYRAZINYL -METHYLOXY - ARYL DERIVATIVES USEFUL AS INHIBITORS OF SPLEEN TYROSINE KINASE (SYK) | Glaxo Group Limited (GB) | 2014-01-15 | — | — | EP | claimed |
| EP-2133340-B1 | Novel benzazepine derivatives | GLAXO GROUP LTD (GB) | 2013-01-16 | — | — | EP | claimed |
| EP-0080779-B1 | 3-BENZAZEPINES AS ALPHA-2 ANTAGONISTS | SMITHKLINE BECKMAN CORPORATION (US) | 1986-07-16 | — | — | EP | claimed |
| EP-0103961-B1 | ALLYLOXY- AND ALLYLTHIO-2,3,4,5-TETRAHYDRO-1H-3-BENZAZEPINES | SMITHKLINE BECKMAN CORPORATION (US) | 1986-04-02 | — | — | EP | claimed |
| EP-0153400-A1 | BENZAZEPINE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND PROCESSES FOR THE PREPARATION OF SUCH COMPOUNDS AND COMPOSITIONS | SCHERING CORPORATION (US) | 1985-09-04 | — | — | EP | claimed |
| WO-1985000808-A1 | BENZAZEPINE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND PROCESSES FOR THE PREPARATION OF SUCH COMPOUNDS AND COMPOSITIONS | SCHERING CORP. (US) | 1985-02-28 | — | — | WO | claimed |
| US-4496558-A | Pharmaceutical compositions and methods for producing alpha antagonism | SMITHKLINE BECKMAN CORPORATION (US) | 1985-01-29 | — | — | US | claimed |
| EP-0108170-A1 | 3-Benzazepines as alpha-2 antagonists | SMITHKLINE BECKMAN CORPORATION (US) | 1984-05-16 | — | — | EP | claimed |
| EP-0044709-B1 | NEW DOPAMINERGIC BENZAZEPINES | SMITHKLINE BECKMAN CORPORATION (US) | 1984-03-14 | — | — | EP | claimed |
| EP-0022330-B1 | SYNERGISTIC ANTIHYPERTENSIVE COMPOSITIONS | SMITHKLINE BECKMAN CORPORATION (US) | 1983-12-21 | — | — | EP | claimed |
| EP-0080779-A1 | 3-Benzazepines as alpha-2 antagonists | SMITHKLINE BECKMAN CORPORATION (US) | 1983-06-08 | — | — | EP | claimed |
| EP-0020107-B1 | 3-ALLYL-7,8-DIHYDROXY-6-HALO-1-(4-HYDROXYPHENYL)-2,3,4,5-TETRAHYDRO-1H-3-BENZAZEPINE DERIVATIVES, PROCESS FOR PREPARING THEM AND COMPOSITIONS CONTAINING THEM | SMITHKLINE BECKMAN CORPORATION (US) | 1982-08-11 | — | — | EP | claimed |