Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 15/20 | 0.76 |
| ▸ | APP | P05067 | 4/20 | 0.76 |
| ▸ | MAPT | P10636 | 3/20 | 0.62 |
| ▸ | CTSL | P07711 | 1/20 | 0.54 |
| ▸ | CTSB | P07858 | 1/20 | 0.54 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.54 |
| ▸ | AKR1B10 | O60218 | 1/20 | 0.53 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1646358 | 1.00 | BACE1 (0.76) | BACE1APPMAPTCTSLCTSB | |
| SCHEMBL1648672 | 0.87 | BACE1 (1.00) | BACE1APP | |
| SCHEMBL1648673 | 0.87 | BACE1 (1.00) | BACE1APP | |
| SCHEMBL9234911 | 0.87 | APP (1.00) | BACE1APPMAPTCTSLCTSB | |
| SCHEMBL9234919 | 0.87 | APP (1.00) | BACE1APPMAPTCTSLCTSB | |
| SCHEMBL1648575 | 0.86 | BACE1 (0.74) | BACE1APPMAPTAKR1B10AKR1B1 | |
| SCHEMBL1648577 | 0.86 | BACE1 (0.74) | BACE1APPMAPTAKR1B10AKR1B1 | |
| SCHEMBL1646697 | 0.85 | BACE1 (1.00) | BACE1APPMAPTTDP1AKR1B1 | |
| SCHEMBL1645650 | 0.85 | BACE1 (1.00) | BACE1APPMAPTTDP1 | |
| SCHEMBL1645648 | 0.85 | BACE1 (1.00) | BACE1APPMAPTTDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8552220-B2 | Therapeutic agent for Alzheimer's disease | TOKYO INSTITUTE OF TECHNOLOGY (JP) | 2013-10-08 | — | — | US | disclosed |
| EP-2305629-A1 | THERAPEUTIC AGENT FOR ALZHEIMER'S DISEASE | Tokyo Institute of Technology (JP) | 2011-04-06 | — | — | EP | disclosed |