Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 11/20 | 0.74 |
| ▸ | APP | P05067 | 3/20 | 0.58 |
| ▸ | MAPT | P10636 | 3/20 | 0.56 |
| ▸ | AKR1B10 | O60218 | 2/20 | 0.53 |
| ▸ | AKR1B1 | P15121 | 2/20 | 0.53 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1648575 | 1.00 | BACE1 (0.74) | BACE1APPMAPTAKR1B10AKR1B1 | |
| SCHEMBL1646352 | 0.86 | BACE1 (0.76) | BACE1APPMAPTAKR1B10AKR1B1 | |
| SCHEMBL1646358 | 0.86 | BACE1 (0.76) | BACE1APPMAPTAKR1B10AKR1B1 | |
| SCHEMBL1648440 | 0.85 | BACE1 (1.00) | BACE1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL1648443 | 0.85 | BACE1 (1.00) | BACE1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL1646337 | 0.85 | BACE1 (0.73) | BACE1APPMAPTAKR1B10AKR1B1 | |
| SCHEMBL1646332 | 0.85 | BACE1 (0.73) | BACE1APPMAPTAKR1B10AKR1B1 | |
| SCHEMBL1646231 | 0.82 | BACE1 (0.82) | BACE1MAPTSMN1; SMN2MEN1KMT2A | |
| SCHEMBL1646226 | 0.82 | BACE1 (0.82) | BACE1MAPTSMN1; SMN2MEN1KMT2A | |
| SCHEMBL1648284 | 0.81 | BACE1 (0.77) | BACE1NPC1RAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8552220-B2 | Therapeutic agent for Alzheimer's disease | TOKYO INSTITUTE OF TECHNOLOGY (JP) | 2013-10-08 | — | — | US | disclosed |
| EP-2305629-A1 | THERAPEUTIC AGENT FOR ALZHEIMER'S DISEASE | Tokyo Institute of Technology (JP) | 2011-04-06 | — | — | EP | disclosed |