Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHIA | Q9BZP6 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | HTR7 | P34969 | 1/20 | 0.38 |
| ▸ | CYP46A1 | Q9Y6A2 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17094786 | 0.85 | CHIA (0.41) | CHIALMNAKDM4E | |
| SCHEMBL16466327 | 0.83 | KDM4E (0.43) | CHIALMNAMTNR1AALDH1A1KDM4E | |
| SCHEMBL16466326 | 0.83 | KDM4E (0.43) | CHIALMNAMTNR1AALDH1A1KDM4E | |
| SCHEMBL16462753 | 0.83 | XIAP (0.47) | CHIALMNAALDH1A1KDM4ECYP1A2 | |
| SCHEMBL16466185 | 0.81 | KDM4E (0.39) | CHIAMTNR1AKDM4E | |
| SCHEMBL16465007 | 0.80 | NR1D1 (0.42) | ALDH1A1KDM4E | |
| SCHEMBL16465263 | 0.78 | XIAP (0.60) | — | |
| SCHEMBL16464394 | 0.78 | XIAP (0.60) | — | |
| SCHEMBL16465261 | 0.78 | XIAP (0.60) | — | |
| SCHEMBL16466120 | 0.77 | XIAP (0.45) | LMNAALDH1A1KDM4ECYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2906559-A1 | AZAINDOLINES | F. Hoffmann-La Roche AG (CH) | 2015-08-19 | — | — | EP | disclosed |
| WO-2014056871-A1 | AZAINDOLINES | F. HOFFMANN-LA ROCHE AG (CH) | 2014-04-17 | — | — | WO | disclosed |