Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDC7 | O00311 | 5/20 | 0.52 |
| ▸ | DBF4 | Q9UBU7 | 1/20 | 0.51 |
| ▸ | NPC1 | O15118 | 3/20 | 0.50 |
| ▸ | RAB9A | P51151 | 3/20 | 0.50 |
| ▸ | PARP1 | P09874 | 1/20 | 0.48 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.47 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.42 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.42 |
| ▸ | FEN1 | P39748 | 1/20 | 0.42 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.42 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.42 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.42 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.42 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.42 |
| ▸ | ACVR2B | Q13705 | 1/20 | 0.42 |
| ▸ | MYLK | Q15746 | 1/20 | 0.42 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.42 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.42 |
| ▸ | PRKD2 | Q9BZL6 | 1/20 | 0.42 |
| ▸ | NLK | Q9UBE8 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29058641 | 0.88 | NPC1 (0.52) | CDC7DBF4NPC1RAB9AADORA2A | |
| SCHEMBL30395416 | 0.88 | NPC1 (0.52) | CDC7DBF4NPC1RAB9AADORA2A | |
| SCHEMBL29058668 | 0.83 | KMT2A (0.43) | CDC7DBF4NPC1RAB9AADORA2A | |
| SCHEMBL30395322 | 0.83 | KMT2A (0.43) | CDC7DBF4NPC1RAB9AADORA2A | |
| SCHEMBL15648676 | 0.79 | ADORA2A (0.56) | CDC7DBF4NPC1ADORA2AALOX5AP | |
| SCHEMBL4560200 | 0.78 | CDC7 (0.56) | CDC7PARP1ADORA2AADORA1JAK2 | |
| SCHEMBL18351966 | 0.78 | ADORA1 (0.51) | CDC7PARP1ADORA2AMAPK10ADORA1 | |
| SCHEMBL15622225 | 0.77 | SIRT1 (0.52) | CDC7ADORA2AEPAS1ADORA1KDM4E | |
| SCHEMBL15621842 | 0.77 | CDC7 (0.42) | CDC7 | |
| SCHEMBL4183400 | 0.76 | CDC7 (0.72) | CDC7PRKD3MAPK9ROCK1PRKD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2903970-A2 | SUBSTITUTED PYRIMIDINYL KINASE INHIBITORS | Portola Pharmaceuticals, Inc. (US) | 2015-08-12 | — | — | EP | claimed |
| WO-2014058921-A2 | SUBSTITUTED PYRIMIDINYL KINASE INHIBITORS | PORTOLA PHARMACEUTICALS, INC. (US) | 2014-04-17 | — | — | WO | claimed |