Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 11/20 | 0.50 |
| ▸ | RAB9A | P51151 | 10/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.43 |
| ▸ | HTT | P42858 | 2/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 4/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 3/20 | 0.43 |
| ▸ | RECQL | P46063 | 1/20 | 0.43 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.42 |
| ▸ | CASP3 | P42574 | 1/20 | 0.42 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.42 |
| ▸ | RELA | Q04206 | 1/20 | 0.42 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL164439 | 0.86 | ABCG2 (0.53) | NPC1RAB9AALDH1A1SMN1; SMN2MAPK1 | |
| SCHEMBL23625878 | 0.85 | ALDH1A1 (0.47) | NPC1RAB9AALDH1A1SMN1; SMN2MAPK1 | |
| SCHEMBL31615498 | 0.81 | NPC1 (0.58) | NPC1RAB9ASMN1; SMN2KDM4EHTT | |
| SCHEMBL163673 | 0.78 | NPC1 (0.44) | NPC1RAB9AALDH1A1SMN1; SMN2MAPK1 | |
| SCHEMBL25064019 | 0.78 | NPC1 (0.49) | NPC1RAB9AALDH1A1SMN1; SMN2MAPK1 | |
| SCHEMBL25063701 | 0.77 | NPC1 (0.43) | NPC1RAB9AALDH1A1SMN1; SMN2MAPK1 | |
| SCHEMBL23625653 | 0.76 | NPC1 (0.42) | NPC1RAB9AALDH1A1SMN1; SMN2MAPK1 | |
| SCHEMBL27930842 | 0.75 | NPC1 (0.46) | NPC1RAB9AALDH1A1SMN1; SMN2MAPK1 | |
| SCHEMBL29072516 | 0.74 | NPC1 (0.71) | NPC1RAB9AALDH1A1SMN1; SMN2KDM4E | |
| SCHEMBL161689 | 0.73 | KMT2A (0.43) | NPC1RAB9AALDH1A1TDP1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 39 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2611786-B1 | NEW COMPOSITIONS AND METHODS FOR CONTROLLING NEMATODE PESTS | MONSANTO TECHNOLOGY LLC (US) | 2019-06-12 | — | — | EP | claimed |
| US-9907306-B2 | Compositions and methods for controlling nematode pests | MONSANTO TECHNOLOGY LLC (US) | 2018-03-06 | — | — | US | claimed |
| US-20160227780-A1 | COMPOSITIONS AND METHODS FOR CONTROLLING NEMATODE PESTS | MONSANTO TECHNOLOGY LLC (US) | 2016-08-11 | — | — | US | claimed |
| US-9339035-B2 | Compositions and methods for controlling nematode pests | MONSANTO TECHNOLOGY LLC (US) | 2016-05-17 | — | — | US | claimed |
| US-20130303368-A1 | NEW COMPOSITIONS AND METHODS FOR CONTROLLING NEMATODE PESTS | MONSANTO TECHNOLOGY LLC (US) | 2013-11-14 | — | — | US | claimed |
| EP-2611786-B1 | NEW COMPOSITIONS AND METHODS FOR CONTROLLING NEMATODE PESTS | MONSANTO TECHNOLOGY LLC (US) | 2019-06-12 | — | — | EP | disclosed |
| EP-2611786-B1 | NEW COMPOSITIONS AND METHODS FOR CONTROLLING NEMATODE PESTS | MONSANTO TECHNOLOGY LLC (US) | 2019-06-12 | — | — | EP | disclosed |
| US-9907306-B2 | Compositions and methods for controlling nematode pests | MONSANTO TECHNOLOGY LLC (US) | 2018-03-06 | — | — | US | disclosed |
| US-9907306-B2 | Compositions and methods for controlling nematode pests | MONSANTO TECHNOLOGY LLC (US) | 2018-03-06 | — | — | US | disclosed |
| US-9907306-B2 | Compositions and methods for controlling nematode pests | MONSANTO TECHNOLOGY LLC (US) | 2018-03-06 | — | — | US | disclosed |
| US-9868719-B2 | Compounds with pesticidal activity | BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) | 2018-01-16 | — | — | US | disclosed |
| EP-3024330-B1 | IMIDAZOTHIA(DIA)ZOLE SULFONAMIDES AS NEMATICIDES | BAYER CROPSCIENCE AG (DE) | 2017-08-30 | — | — | EP | disclosed |
| WO-2015007668-A1 | HETEROCYCLIC SULFONYLAMINO(THIO)CARBONYL-DERIVATIVES WITH NEMATICIDAL PROPERTIES | BAYER CROPSCIENCE AG (DE) | 2015-01-22 | — | — | WO | disclosed |
| US-20130303368-A1 | NEW COMPOSITIONS AND METHODS FOR CONTROLLING NEMATODE PESTS | MONSANTO TECHNOLOGY LLC (US) | 2013-11-14 | — | — | US | disclosed |
| US-20130303368-A1 | NEW COMPOSITIONS AND METHODS FOR CONTROLLING NEMATODE PESTS | MONSANTO TECHNOLOGY LLC (US) | 2013-11-14 | — | — | US | disclosed |
| US-20130303368-A1 | NEW COMPOSITIONS AND METHODS FOR CONTROLLING NEMATODE PESTS | MONSANTO TECHNOLOGY LLC (US) | 2013-11-14 | — | — | US | disclosed |
| CN-103221397-A | Novel compositions and methods for controlling nematode pests | MONSANTO TECHNOLOGY LLC | 2013-07-24 | — | — | CN | disclosed |
| EP-2611786-A1 | NEW COMPOSITIONS AND METHODS FOR CONTROLLING NEMATODE PESTS | Monsanto Technology LLC (US) | 2013-07-10 | — | — | EP | disclosed |
| WO-2012030887-A1 | NEW COMPOSITIONS AND METHODS FOR CONTROLLING NEMATODE PESTS | DIVERGENCE, INC. (US) | 2012-03-08 | — | — | WO | disclosed |
| WO-2012030887-A1 | NEW COMPOSITIONS AND METHODS FOR CONTROLLING NEMATODE PESTS | DIVERGENCE, INC. (US) | 2012-03-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130303368-A1 | NEW COMPOSITIONS AND METHODS FOR CONTROLLING NEMATODE PESTS | PTMS, TUBA3C, TUBA1C | NPC1 2710/4885RAB9A 1454/4885ALDH1A1 3893/4885 |
| US-20160227780-A1 | COMPOSITIONS AND METHODS FOR CONTROLLING NEMATODE PESTS | PTMS, TUBA3C, TUBA1C | NPC1 2646/4885RAB9A 1599/4885ALDH1A1 3632/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.