Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S1PR1 | P21453 | 5/20 | 0.56 |
| ▸ | FOLH1 | Q04609 | 2/20 | 0.48 |
| ▸ | LTA4H | P09960 | 2/20 | 0.43 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | CASR | P41180 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | S1PR3 | Q99500 | 2/20 | 0.41 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.41 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | IDO1 | P14902 | 1/20 | 0.40 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.40 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.40 |
| ▸ | PLAAT3 | P53816 | 1/20 | 0.40 |
| ▸ | PLAAT5 | Q96KN8 | 1/20 | 0.40 |
| ▸ | PLAAT2 | Q9NWW9 | 1/20 | 0.40 |
| ▸ | PLAAT4 | Q9UL19 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16489861 | 0.95 | S1PR1 (0.52) | S1PR1FOLH1CHRM2SMN1; SMN2CASR | |
| SCHEMBL16468792 | 0.87 | S1PR1 (0.73) | S1PR1FOLH1CHRM2CASRADRB1 | |
| SCHEMBL16469145 | 0.84 | S1PR1 (0.58) | S1PR1FOLH1CHRM2CASRS1PR3 | |
| SCHEMBL16469104 | 0.81 | LMNA (0.41) | S1PR1CASRALDH1A1KMT2ATP53 | |
| SCHEMBL16468949 | 0.80 | S1PR1 (0.42) | S1PR1CHRM2CASRKMT2ATP53 | |
| SCHEMBL16506665 | 0.78 | S1PR1 (0.77) | S1PR1FOLH1SMN1; SMN2ALDH1A1KMT2A | |
| SCHEMBL16506178 | 0.77 | S1PR1 (0.78) | S1PR1FOLH1SMN1; SMN2ALDH1A1KMT2A | |
| SCHEMBL15194131 | 0.75 | S1PR1 (0.72) | S1PR1FOLH1LTA4HS1PR3S1PR5 | |
| SCHEMBL16470812 | 0.75 | S1PR5 (0.46) | S1PR1KMT2AS1PR5 | |
| SCHEMBL15192010 | 0.75 | S1PR1 (0.72) | S1PR1FOLH1ADRB1ADRB3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20150051176-A1 | ARYL DERIVATIVES AS SPHINGOSINE-1 PHOSPHATE RECEPTORS MODULATORS | ALLERGAN, INC. | 2015-02-19 | — | — | US | claimed |
| WO-2015023837-A1 | ARYL DERIVATIVES AS SPHINGOSINE-1 PHOSPHATE RECEPTORS MODULATORS | ALLERGAN, INC. (US) | 2015-02-19 | — | — | WO | claimed |
| US-20150051176-A1 | ARYL DERIVATIVES AS SPHINGOSINE-1 PHOSPHATE RECEPTORS MODULATORS | ALLERGAN, INC. | 2015-02-19 | — | — | US | disclosed |
| WO-2015023837-A1 | ARYL DERIVATIVES AS SPHINGOSINE-1 PHOSPHATE RECEPTORS MODULATORS | ALLERGAN, INC. (US) | 2015-02-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150051176-A1 | ARYL DERIVATIVES AS SPHINGOSINE-1 PHOSPHATE RECEPTORS MODULATORS | S1PR1, S1PR3, S1PR2 | S1PR1 1/4885FOLH1 1935/4885LTA4H 983/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.