Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 8/20 | 0.48 |
| ▸ | KDR | P35968 | 4/20 | 0.46 |
| ▸ | TEK | Q02763 | 3/20 | 0.45 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.44 |
| ▸ | CDK1 | P06493 | 1/20 | 0.44 |
| ▸ | CDK2 | P24941 | 1/20 | 0.44 |
| ▸ | BRAF | P15056 | 3/20 | 0.43 |
| ▸ | RAF1 | P04049 | 1/20 | 0.42 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.41 |
| ▸ | RET | P07949 | 1/20 | 0.41 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.41 |
| ▸ | LTK | P29376 | 1/20 | 0.41 |
| ▸ | FLT3 | P36888 | 1/20 | 0.41 |
| ▸ | CDK8 | P49336 | 1/20 | 0.41 |
| ▸ | NTRK3 | Q16288 | 1/20 | 0.41 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.41 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.41 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.41 |
| ▸ | IGF1R | P08069 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1323476 | 0.81 | RIPK1 (0.54) | RIPK1KDRTEKEPHB4CDK1 | |
| SCHEMBL4872168 | 0.73 | RIPK1 (0.57) | RIPK1KDRTEKEPHB4CDK1 | |
| SCHEMBL1322572 | 0.71 | FLT3 (0.52) | RIPK1KDRTEKNTRK1RET | |
| SCHEMBL16456547 | 0.71 | RIPK1 (0.54) | RIPK1KDRTEKEPHB4CDK1 | |
| SCHEMBL14014078 | 0.69 | GRIK1 (0.60) | RIPK1KDRBRAFNTRK1RET | |
| SCHEMBL1323384 | 0.68 | TEK (0.46) | RIPK1KDRTEKBRAFRAF1 | |
| SCHEMBL2264236 | 0.68 | KDR (0.58) | RIPK1KDRBRAFNTRK1 | |
| SCHEMBL5271094 | 0.67 | KDR (0.69) | RIPK1KDRTEKEPHB4NTRK1 | |
| SCHEMBL16008793 | 0.67 | GRIK1 (0.58) | RIPK1KDRBRAFNTRK1 | |
| SCHEMBL4515186 | 0.66 | TRPV1 (0.66) | RIPK1KDRTEKEPHB4BRAF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1912988-B1 | 7-SUBSTITUTED AZA-INDAZOLES, COMPOSITIONS CONTAINING SAME, PRODUCTION METHOD AND USE THEREOF | AVENTIS PHARMA SA (FR) | 2014-04-16 | — | — | EP | disclosed |