Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT2 | Q8IXJ6 | 9/20 | 0.40 |
| ▸ | SIRT1 | Q96EB6 | 9/20 | 0.40 |
| ▸ | SIRT3 | Q9NTG7 | 9/20 | 0.40 |
| ▸ | AURKA | O14965 | 2/20 | 0.40 |
| ▸ | RPS6KB1 | P23443 | 2/20 | 0.40 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | BACE1 | P56817 | 4/20 | 0.39 |
| ▸ | PARP1 | P09874 | 1/20 | 0.39 |
| ▸ | HRH4 | Q9H3N8 | 2/20 | 0.37 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.37 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10193147 | 0.85 | BACE1 (0.47) | SIRT2SIRT1SIRT3BACE1 | |
| SCHEMBL10155847 | 0.81 | BACE1 (0.59) | BACE1 | |
| SCHEMBL10193014 | 0.80 | BACE1 (0.46) | SIRT2SIRT1SIRT3BACE1HRH4 | |
| SCHEMBL10192928 | 0.78 | BACE1 (0.46) | SIRT2SIRT1SIRT3ALDH1A1BACE1 | |
| SCHEMBL10193824 | 0.78 | BACE1 (0.45) | BACE1HRH4HRH3 | |
| SCHEMBL10193935 | 0.78 | BACE1 (0.45) | SIRT2SIRT1SIRT3BACE1HRH4 | |
| SCHEMBL10193785 | 0.77 | BACE1 (0.48) | SIRT2SIRT1SIRT3BACE1 | |
| SCHEMBL10155870 | 0.76 | BACE1 (0.57) | BACE1 | |
| SCHEMBL10193222 | 0.75 | ALDH1A1 (0.51) | AURKARPS6KB1ALDH1A1TDP1BACE1 | |
| SCHEMBL10192932 | 0.75 | BACE1 (0.46) | SIRT2SIRT1SIRT3ALDH1A1BACE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1942105-B1 | AMINODIHYDROTHIAZINE DERIVATIVE | SHIONOGI & CO (JP) | 2014-04-16 | — | — | EP | disclosed |