Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 13/20 | 0.48 |
| ▸ | MTOR | P42345 | 7/20 | 0.46 |
| ▸ | PIK3CD | O00329 | 4/20 | 0.46 |
| ▸ | PIK3CB | P42338 | 4/20 | 0.46 |
| ▸ | PIK3R1 | P27986 | 4/20 | 0.46 |
| ▸ | PIK3CG | P48736 | 3/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.46 |
| ▸ | RPTOR | Q8N122 | 4/20 | 0.44 |
| ▸ | MLST8 | Q9BVC4 | 4/20 | 0.44 |
| ▸ | RICTOR | Q6R327 | 3/20 | 0.44 |
| ▸ | MAPKAP1 | Q9BPZ7 | 3/20 | 0.44 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.43 |
| ▸ | ATR | Q13535 | 1/20 | 0.43 |
| ▸ | MAP3K12 | Q12852 | 6/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL336266 | 0.90 | PIK3CA (0.56) | PIK3CAMTORPIK3CDPIK3CBPIK3R1 | |
| SCHEMBL336979 | 0.84 | PIK3CA (0.67) | PIK3CAMTORPIK3CDPIK3CBPIK3R1 | |
| SCHEMBL799640 | 0.80 | PIK3CA (0.62) | PIK3CAMTORPIK3CDPIK3CBPIK3R1 | |
| SCHEMBL13674676 | 0.78 | PIK3CA (0.60) | PIK3CAMTORPIK3CDPIK3CBPIK3R1 | |
| SCHEMBL336390 | 0.76 | PIK3CA (0.57) | PIK3CAMTORPIK3CDPIK3CBPIK3R1 | |
| SCHEMBL799327 | 0.74 | MTOR (0.52) | PIK3CAMTORPIK3CDPIK3CBPIK3R1 | |
| SCHEMBL337181 | 0.72 | PIK3CA (0.62) | PIK3CAMTORPIK3CDPIK3CBPIK3R1 | |
| Bicarbonate SCHEMBL13674675 | 0.72 | HDAC1 (0.53) | PIK3CAMTORPIK3CDPIK3CBPIK3R1 | |
| SCHEMBL336204 | 0.71 | PIK3CA (0.67) | PIK3CAMTORPIK3CDPIK3CBPIK3R1 | |
| SCHEMBL336242 | 0.71 | MTOR (0.47) | PIK3CAMTORPIK3CDRPTORMLST8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2336132-B1 | MORPHOLINOPURINE DERIVATIVE | DAIICHI SANKYO CO LTD (JP) | 2014-01-01 | — | — | EP | disclosed |