Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 15/20 | 0.57 |
| ▸ | MTOR | P42345 | 13/20 | 0.57 |
| ▸ | PIK3R1 | P27986 | 8/20 | 0.57 |
| ▸ | RPTOR | Q8N122 | 8/20 | 0.57 |
| ▸ | MLST8 | Q9BVC4 | 8/20 | 0.57 |
| ▸ | RICTOR | Q6R327 | 7/20 | 0.57 |
| ▸ | MAPKAP1 | Q9BPZ7 | 7/20 | 0.57 |
| ▸ | PIK3CD | O00329 | 5/20 | 0.57 |
| ▸ | PIK3CB | P42338 | 3/20 | 0.57 |
| ▸ | PIK3CG | P48736 | 3/20 | 0.57 |
| ▸ | PIK3C3 | Q8NEB9 | 2/20 | 0.57 |
| ▸ | ATR | Q13535 | 2/20 | 0.55 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.47 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.47 |
| ▸ | ATRIP | Q8WXE1 | 1/20 | 0.47 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.47 |
| ▸ | MAP3K12 | Q12852 | 2/20 | 0.47 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL799640 | 0.90 | PIK3CA (0.62) | PIK3CAMTORPIK3R1RPTORMLST8 | |
| SCHEMBL336266 | 0.86 | PIK3CA (0.56) | PIK3CAMTORPIK3R1RPTORMLST8 | |
| SCHEMBL336770 | 0.84 | PIK3CA (0.55) | PIK3CAMTORPIK3R1RPTORMLST8 | |
| SCHEMBL336286 | 0.81 | MTOR (0.48) | PIK3CAMTORPIK3R1RPTORMLST8 | |
| SCHEMBL336264 | 0.80 | PIK3CA (0.51) | PIK3CAMTORPIK3R1RPTORMLST8 | |
| SCHEMBL337225 | 0.78 | PIK3CA (0.49) | PIK3CAMTORPIK3R1RPTORMLST8 | |
| SCHEMBL2865554 | 0.78 | PIK3CA (0.62) | PIK3CAMTORPIK3R1RPTORMLST8 | |
| SCHEMBL337219 | 0.77 | PIK3CA (0.48) | PIK3CAMTORPIK3R1RPTORMLST8 | |
| SCHEMBL16473589 | 0.76 | PIK3CA (0.48) | PIK3CAMTORPIK3R1RPTORMLST8 | |
| SCHEMBL336267 | 0.76 | PIK3CA (0.47) | PIK3CAMTORPIK3R1RPTORMLST8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102245607-B | Morpholinopurine derivative | DAIICHI SANKYO CO LTD | 2014-07-02 | — | — | CN | disclosed |
| EP-2336132-B1 | MORPHOLINOPURINE DERIVATIVE | DAIICHI SANKYO CO LTD (JP) | 2014-01-01 | — | — | EP | disclosed |
| US-8309546-B2 | Morpholinopurine derivatives | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2012-11-13 | — | — | US | disclosed |
| US-8309546-B2 | Morpholinopurine derivatives | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2012-11-13 | — | — | US | disclosed |
| US-8309546-B2 | Morpholinopurine derivatives | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2012-11-13 | — | — | US | disclosed |
| US-20120071476-A1 | MORPHOLINOPURINE DERIVATIVES | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2012-03-22 | — | — | US | disclosed |
| US-20120071476-A1 | MORPHOLINOPURINE DERIVATIVES | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2012-03-22 | — | — | US | disclosed |
| US-20120071476-A1 | MORPHOLINOPURINE DERIVATIVES | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2012-03-22 | — | — | US | disclosed |
| US-8097622-B2 | Morpholinopurine derivatives | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2012-01-17 | — | — | US | disclosed |
| US-8097622-B2 | Morpholinopurine derivatives | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2012-01-17 | — | — | US | disclosed |
| US-8097622-B2 | Morpholinopurine derivatives | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2012-01-17 | — | — | US | disclosed |
| CN-102245607-A | Morpholinopurine derivative | DAIICHI SANKYO CO LTD | 2011-11-16 | — | — | CN | disclosed |
| EP-2336132-A1 | MORPHOLINOPURINE DERIVATIVE | Daiichi Sankyo Company, Limited (JP) | 2011-06-22 | — | — | EP | disclosed |
| US-20100130492-A1 | MORPHOLINOPURINE DERIVATIVES | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2010-05-27 | — | — | US | disclosed |
| US-20100130492-A1 | MORPHOLINOPURINE DERIVATIVES | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2010-05-27 | — | — | US | disclosed |
| US-20100130492-A1 | MORPHOLINOPURINE DERIVATIVES | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2010-05-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100130492-A1 | MORPHOLINOPURINE DERIVATIVES | MTOR, RICTOR, PIK3R1 | PIK3CA 22/4885MTOR 1/4885PIK3R1 3/4885 |
| US-20120071476-A1 | MORPHOLINOPURINE DERIVATIVES | MTOR, RICTOR, PIK3R1 | PIK3CA 22/4885MTOR 1/4885PIK3R1 3/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.