Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.42 |
| ▸ | HTT | P42858 | 3/20 | 0.39 |
| ▸ | ACHE | P22303 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | PHLPP2 | Q6ZVD8 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | JAK2 | O60674 | 1/20 | 0.35 |
| ▸ | MITF | O75030 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1646716 | 0.85 | MAPT (0.40) | MAPTHTTACHEHSD17B10ALDH1A1 | |
| SCHEMBL943658 | 0.83 | MAPT (0.57) | MAPTHTTACHEHSD17B10ALDH1A1 | |
| SCHEMBL943613 | 0.81 | NOS1 (0.43) | ACHEPOLBKDM4ENOS3NOS1 | |
| SCHEMBL942774 | 0.80 | MAPT (0.52) | MAPTHTTACHEHSD17B10ALDH1A1 | |
| SCHEMBL1645549 | 0.77 | MAPT (0.46) | MAPTHTTL3MBTL1NPSR1TSHR | |
| SCHEMBL942649 | 0.74 | MAPT (0.45) | MAPTHTTACHEHSD17B10ALDH1A1 | |
| SCHEMBL6941718 | 0.72 | MAPT (0.57) | MAPTHTTACHEHSD17B10ALDH1A1 | |
| SCHEMBL3158429 | 0.72 | MAPT (0.76) | MAPTHTTACHEHSD17B10ALDH1A1 | |
| SCHEMBL1993805 | 0.71 | MAPT (0.45) | MAPTHTTALDH1A1L3MBTL1MAPK1 | |
| SCHEMBL1645594 | 0.71 | KCNH2 (0.51) | MAPTHTTALDH1A1KMT2ACHRNB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2303329-A1 | ANTIFUNGAL COMBINATION THERAPY | F2G Limited (GB) | 2011-04-06 | — | — | EP | disclosed |
| WO-2009144473-A1 | ANTIFUNGAL COMBINATION THERAPY | F2G LIMITED (GB) | 2009-12-03 | — | — | WO | disclosed |